Skip to main content

Articles

Page 52 of 65

  1. Trichostatin A (TSA), a potent inhibitor of histone deacetylases exhibits strong anti-tumor and growth inhibitory activities, but its mechanism(s) of action is not completely understood. Osteopontin (OPN) is a...

    Authors: Priyanka Sharma, Santosh Kumar and Gopal C Kundu
    Citation: Molecular Cancer 2010 9:178
    Content type: Research Published on:

  2. Barrett's esophagus (BE) is caused by gastroesophageal reflux with consecutive mucosal inflammation, predisposing patients to the development of esophageal adenocarcinoma (EAC). We investigated changes in T ce...

    Authors: Uta Berndt, Lars Philipsen, Sebastian Bartsch, Yuqin Hu, Christoph Röcken, Wiedenmann Bertram, Marcus Hämmerle, Thomas Rösch and Andreas Sturm
    Citation: Molecular Cancer 2010 9:177
    Content type: Research Published on:

  3. Components of the microenvironment such as bone marrow stromal cells (BMSCs) are well known to support multiple myeloma (MM) disease progression and resistance to chemotherapy including the proteasome inhibito...

    Authors: Stephanie Markovina, Natalie S Callander, Shelby L O'Connor, Guangwu Xu, Yufang Shi, Catherine P Leith, KyungMann Kim, Parul Trivedi, Jaehyup Kim, Peiman Hematti and Shigeki Miyamoto
    Citation: Molecular Cancer 2010 9:176
    Content type: Research Published on:

  4. The oncolytic adenovirus dl 922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers. dl 922-947 is more potent than wild type adenovirus and the...

    Authors: Magdalena B Flak, Claire M Connell, Claude Chelala, Kyra Archibald, Michael A Salako, Katrina J Pirlo, Michelle Lockley, Sally P Wheatley, Frances R Balkwill and Iain A McNeish
    Citation: Molecular Cancer 2010 9:175
    Content type: Research Published on:

  5. Prostate cancer is the second leading cause of cancer mortality in American men. Although serum PSA testing is widely used for early detection, more specific prognostic tests are needed to guide treatment deci...

    Authors: Matthias Jost, John R Day, Ryan Slaughter, Theodore D Koreckij, Deanna Gonzales, Martin Kinnunen, Jack Groskopf, Harry G Rittenhouse, Robert L Vessella and Mark A Reynolds
    Citation: Molecular Cancer 2010 9:174
    Content type: Research Published on:

  6. The tumor suppressor pRb plays a key role regulating cell cycle arrest, and disturbances in the RB1 gene have been reported in different cancer forms. However, the literature reports contradictory findings with r...

    Authors: Elisabet Ognedal Berge, Stian Knappskog, Stephanie Geisler, Vidar Staalesen, Marec Pacal, Anne-Lise Børresen-Dale, Pål Puntervoll, Johan Richard Lillehaug and Per Eystein Lønning
    Citation: Molecular Cancer 2010 9:173
    Content type: Research Published on:

  7. A hallmark of several human cancers is loss of heterozygosity (LOH) of chromosome 17p13. The same chromosomal region is also frequently hypermethylated in cancer. Although loss of 17p13 has been often associat...

    Authors: M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino and Edoardo Alesse
    Citation: Molecular Cancer 2010 9:172
    Content type: Short communication Published on:

  8. The transcription factor Runx2 has an established role in cancers that metastasize to bone. In metastatic breast cancer cells Runx2 is overexpressed and contributes to the invasive capacity of the cells by reg...

    Authors: Daniel Mendoza-Villanueva, Wensheng Deng, Cesar Lopez-Camacho and Paul Shore
    Citation: Molecular Cancer 2010 9:171
    Content type: Research Published on:

  9. Wnt factors control cell differentiation through semi-independent molecular cascades known as the β-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigeneti...

    Authors: Ester Lara, Vincenzo Calvanese, Covadonga Huidobro, Agustin F Fernández, Ángela Moncada-Pazos, Álvaro J Obaya, Oscar Aguilera, José Manuel González-Sancho, Laura Sánchez, Aurora Astudillo, Alberto Muñoz, Carlos López-Otín, Manel Esteller and Mario F Fraga
    Citation: Molecular Cancer 2010 9:170
    Content type: Research Published on:

  10. Recently, the microRNA-200 family was reported to affect cancer biology by regulating epithelial to mesenchymal transition (EMT). Especially, the expression of miR-200c has been shown to be associated with upregu...

    Authors: Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, Norihiro Sato, Tadashi Kayashima, Hayato Fujita, Kouhei Nakata and Masao Tanaka
    Citation: Molecular Cancer 2010 9:169
    Content type: Research Published on:

  11. Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The ...

    Authors: Silke Haubeiss, Jens O Schmid, Thomas E Mürdter, Maike Sonnenberg, Godehard Friedel, Heiko van der Kuip and Walter E Aulitzky
    Citation: Molecular Cancer 2010 9:168
    Content type: Short communication Published on:

  12. A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. Although epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known abo...

    Authors: Saskia M Wilting, Robert AA van Boerdonk, Florianne E Henken, Chris JLM Meijer, Begoňa Diosdado, Gerrit A Meijer, Carlos le Sage, Reuven Agami, Peter JF Snijders and Renske DM Steenbergen
    Citation: Molecular Cancer 2010 9:167
    Content type: Research Published on:

  13. Epidermal growth factor (EGF) and its receptor (EGFR) constitute a principal growth-promoting pathway in endometrial cancer cells. Pre-clinical studies were undertaken to compare the expression of EGFR isoform...

    Authors: Lina Albitar, Gavin Pickett, Marilee Morgan, Jason A Wilken, Nita J Maihle and Kimberly K Leslie
    Citation: Molecular Cancer 2010 9:166
    Content type: Research Published on:

  14. We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT...

    Authors: Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson Jr, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson III, Pui-Kai Li and Gregory B Lesinski
    Citation: Molecular Cancer 2010 9:165
    Content type: Research Published on:

  15. Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models.

    Authors: Henry Zall, Arnim Weber, Robert Besch, Niko Zantl and Georg Häcker
    Citation: Molecular Cancer 2010 9:164
    Content type: Research Published on:

  16. Aberrant promoter DNA methylation has been reported in childhood acute lymphoblastic leukaemia (ALL) and has the potential to contribute to its onset and outcome. However, few reports demonstrate consistent, p...

    Authors: Robert J. Weeks, Ursula R. Kees, Sarah Song and Ian M. Morison
    Citation: Molecular Cancer 2010 9:163
    Content type: Research Published on:

  17. Aberrations in the Wnt pathway have been reported to be involved in the metastasis of prostate cancer (PCa) to bone. We investigated the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, ...

    Authors: David S. Yee, Yaxiong Tang, Xuesen Li, Zhongbo Liu, Yi Guo, Samia Ghaffar, Peter McQueen, Dash Atreya, Jun Xie, Anne R. Simoneau, Bang H. Hoang and Xiaolin Zi
    Citation: Molecular Cancer 2010 9:162
    Content type: Research Published on:

  18. CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of C...

    Authors: Elisabet Ametller, Susana García-Recio, Domizziana Costamagna, Cristina Mayordomo, Patricia Fernández-Nogueira, Neus Carbó, Eva María Pastor-Arroyo, Pedro Gascón and Vanessa Almendro
    Citation: Molecular Cancer 2010 9:161
    Content type: Research Published on:

  19. Germline mutations in the FLCN gene are responsible for the development of fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube' (BHD) syndrome. The encoded protein folliculin (FLCN) is conserved a...

    Authors: Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Jaime Stull, Duy-Tan Ngo, Masaya Baba, Maria J Merino, W Marston Linehan and Laura S Schmidt
    Citation: Molecular Cancer 2010 9:160
    Content type: Research Published on:

  20. Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer poten...

    Authors: Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja and Krzysztof Reiss
    Citation: Molecular Cancer 2010 9:159
    Content type: Research Published on:

  21. The polycomb group (PcG) protein BMI1 is an important regulator of development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell phenotype and oncogenesis. In particular, its overe...

    Authors: Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger and Goberdhan P Dimri
    Citation: Molecular Cancer 2010 9:158
    Content type: Research Published on:

  22. Although several anti-angiogenic therapies have been approved in the treatment of cancer, the survival benefits of such therapies are relatively modest. Discovering new molecules and/or better understating sig...

    Authors: Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck and Xuefen Le Bourhis
    Citation: Molecular Cancer 2010 9:157
    Content type: Research Published on:

  23. Ca2+ is a ubiquitous messenger that has been shown to be responsible for controlling numerous cellular processes including cell growth and cell death. Whereas the involvement of IP3-induced Ca2+ signalling (IICS)...

    Authors: Cécilia Szatkowski, Jan B Parys, Halima Ouadid-Ahidouch and Fabrice Matifat
    Citation: Molecular Cancer 2010 9:156
    Content type: Research Published on:

  24. Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pat...

    Authors: Angela KF Lo, Christopher W Dawson, Kwok W Lo, Yanxing Yu and Lawrence S Young
    Citation: Molecular Cancer 2010 9:155
    Content type: Research Published on:

  25. Formation of tumour cell aggregation/emboli prolongs the survival of circulating tumour cells in the circulation, enhances their physical trapping in the micro-vasculature and thus increases metastatic spread ...

    Authors: Qicheng Zhao, Monica Barclay, John Hilkens, Xiuli Guo, Hannah Barrow, Jonathan M Rhodes and Lu-Gang Yu
    Citation: Molecular Cancer 2010 9:154
    Content type: Research Published on:

  26. Centrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation of cyclin/cyclin-dependent kinase 2 (...

    Authors: Nina Korzeniewski, Sarah Wheeler, Payel Chatterjee, Anette Duensing and Stefan Duensing
    Citation: Molecular Cancer 2010 9:153
    Content type: Research Published on:

  27. Selection of early stage non-small cell lung cancer patients with a high risk of recurrence is warranted in order to select patients who will benefit from adjuvant treatment strategies. We evaluated the progno...

    Authors: Anne-Marie C Dingemans, Vivian van den Boogaart, Bettine A Vosse, Robert-Jan van Suylen, Arjan W Griffioen and Victor L Thijssen
    Citation: Molecular Cancer 2010 9:152
    Content type: Research Published on:

  28. NK- and T-cells are closely related lymphocytes, originating from the same early progenitor cells during hematopoiesis. In these differentiation processes deregulation of developmental genes may contribute to ...

    Authors: Stefan Nagel, Letizia Venturini, Victor E Marquez, Corinna Meyer, Maren Kaufmann, Michaela Scherr, Roderick AF MacLeod and Hans G Drexler
    Citation: Molecular Cancer 2010 9:151
    Content type: Research Published on:

  29. The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERα) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). I...

    Authors: Jerzy Rokicki, Partha M Das, Jennifer M Giltnane, Olivia Wansbury, David L Rimm, Beatrice A Howard and Frank E Jones
    Citation: Molecular Cancer 2010 9:150
    Content type: Short communication Published on:

  30. Pancreatic intraepithelial neoplasias (PanINs) are precursors of malignant pancreatic cancer, an ideal stage for early cancer detection. We applied quantitative proteomics to identify aberrantly elevated prote...

    Authors: Ru Chen, Sheng Pan, Xiaobo Duan, Brad H Nelson, Rob A Sahota, Sarah de Rham, Richard A Kozarek, Martin McIntosh and Teresa A Brentnall
    Citation: Molecular Cancer 2010 9:149
    Content type: Research Published on:

  31. Prostate-derived Ets factor (PDEF) is expressed in tissues of high epithelial content including prostate, although its precise function has not been fully established. Conventional therapies produce a high rat...

    Authors: Thomas R Johnson, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Sarah Venezia, Paul D Maroni, Randall B Meacham and Hari K Koul
    Citation: Molecular Cancer 2010 9:148
    Content type: Research Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2021 20:109

  32. Cisplatin and its derivatives are commonly used anti-cancer drugs. However, cisplatin has clinical limitations including serious side effects and frequent emergence of intrinsic or acquired resistance. Thus, t...

    Authors: Veronika Kvardova, Roman Hrstka, Dawid Walerych, Petr Muller, Eva Matoulkova, Veronika Hruskova, Dagmar Stelclova, Petr Sova and Borivoj Vojtesek
    Citation: Molecular Cancer 2010 9:147
    Content type: Research Published on:

  33. Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths worldwide. It is often diagnosed at an advanced stage, and hence typically has a poor prognosis. To identify distinct molecula...

    Authors: Dilek Colak, Muhammad A Chishti, Al-Bandary Al-Bakheet, Ahmed Al-Qahtani, Mohamed M Shoukri, Malcolm H Goyns, Pinar T Ozand, John Quackenbush, Ben H Park and Namik Kaya
    Citation: Molecular Cancer 2010 9:146
    Content type: Research Published on:

  34. Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other g...

    Authors: Yong-Yu Liu, Vineet Gupta, Gauri A Patwardhan, Kaustubh Bhinge, Yunfeng Zhao, Jianxiong Bao, Harihara Mehendale, Myles C Cabot, Yu-Teh Li and S Michal Jazwinski
    Citation: Molecular Cancer 2010 9:145
    Content type: Research Published on:

  36. Lymphotropism in oral squamous cell carcinoma (OSCC) is one of the most important prognostic factors of 5-year survival. In an effort to identify genes that may be responsible for the initiation of OSCC lympho...

    Authors: Chang Xu, Yan Liu, Pei Wang, Wenhong Fan, Tessa C Rue, Melissa P Upton, John R Houck, Pawadee Lohavanichbutr, David R Doody, Neal D Futran, Lue Ping Zhao, Stephen M Schwartz, Chu Chen and Eduardo Méndez
    Citation: Molecular Cancer 2010 9:143
    Content type: Research Published on:

  37. Prostate cancer shows an extremely slow progression, appearing in its metastatic, hormone refractory phenotype mostly in elderly men. The chemopreventive targeting of this tumor could accordingly delay its mal...

    Authors: Roberto Benelli, Stefano Monteghirfo, Roberta Venè, Francesca Tosetti and Nicoletta Ferrari
    Citation: Molecular Cancer 2010 9:142
    Content type: Research Published on:

  38. Solid tumors are often poorly vascularized, with cells that can be 100 μm away from blood vessels. These distant cells get less oxygen and nutrients and are exposed to lower doses of chemotherapeutic agents. A...

    Authors: Sylvine Cottin, Karim Ghani, Pedro Otavio de Campos-Lima and Manuel Caruso
    Citation: Molecular Cancer 2010 9:141
    Content type: Research Published on:

  39. Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. Lysophosphatid...

    Authors: Molly K Altman, Vashisht Gopal, Wei Jia, Shuangxing Yu, Hassan Hall, Gordon B Mills, A Cary McGinnis, Michael G Bartlett, Guowei Jiang, Damian Madan, Glenn D Prestwich, Yong Xu, Michael A Davies and Mandi M Murph
    Citation: Molecular Cancer 2010 9:140
    Content type: Research Published on:

  40. Cetuximab, an antibody targeting the epidermal growth factor receptor (EGFR), increases survival in patients with advanced EGFR-positive non-small cell lung cancer when administrated in combination with chemot...

    Authors: Yi-Fan Hsu, Daniel Ajona, Leticia Corrales, Jose M Lopez-Picazo, Alfonso Gurpide, Luis M Montuenga and Ruben Pio
    Citation: Molecular Cancer 2010 9:139
    Content type: Research Published on:

  41. New, more effective strategies are needed to treat highly aggressive neuroblastoma. Our laboratory has previously shown that full-length Secreted Protein Acidic and Rich in Cysteine (SPARC) and a SPARC peptide...

    Authors: Alexandre Chlenski, Lisa J Guerrero, Radhika Peddinti, Jared A Spitz, Payton T Leonhardt, Qiwei Yang, Yufeng Tian, Helen R Salwen and Susan L Cohn
    Citation: Molecular Cancer 2010 9:138
    Content type: Research Published on:

  42. Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal,...

    Authors: Marina Pisano, Gabriella Pagnan, Maria Antonietta Dettori, Sara Cossu, Irene Caffa, Ilaria Sassu, Laura Emionite, Davide Fabbri, Michele Cilli, Fabio Pastorino, Giuseppe Palmieri, Giovanna Delogu, Mirco Ponzoni and Carla Rozzo
    Citation: Molecular Cancer 2010 9:137
    Content type: Research Published on:

  43. In a variety of cancers, altered patterns of microRNA (miRNA) expression are reported and may affect the cell cycle and cell survival. Recent studies suggest that the expression level of miRNAs that act as tum...

    Authors: Akio Iio, Yoshihito Nakagawa, Ichiro Hirata, Tomoki Naoe and Yukihiro Akao
    Citation: Molecular Cancer 2010 9:136
    Content type: Short communication Published on:

  46. Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hyp...

    Authors: Olga Méndez, Jiri Zavadil, Mine Esencay, Yevgeniy Lukyanov, Daniel Santovasi, Shu-Chi Wang, Elizabeth W Newcomb and David Zagzag
    Citation: Molecular Cancer 2010 9:133
    Content type: Research Published on:

  47. Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is ...

    Authors: Wenjuan Li, Jiping Zeng, Qiao Li, Li Zhao, Tiantian Liu, Magnus Björkholm, Jihui Jia and Dawei Xu
    Citation: Molecular Cancer 2010 9:132
    Content type: Research Published on:

  48. A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 dru...

    Authors: Chih-Yuan Tseng, Jonathan Y Mane, Philip Winter, Lorelei Johnson, Torin Huzil, Elzbieta Izbicka, Richard F Luduena and Jack A Tuszynski
    Citation: Molecular Cancer 2010 9:131
    Content type: Research Published on:

  49. Human mesenchymal stromal cells (MSC) hold a promise for future cell-based therapies due to their immunomodulatory properties and/or secretory activity. Nevertheless non-neoplastic tumor compartment could also...

    Authors: Lucia Kucerova, Miroslava Matuskova, Kristina Hlubinova, Veronika Altanerova and Cestmir Altaner
    Citation: Molecular Cancer 2010 9:129
    Content type: Research Published on:

  50. Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a...

    Authors: Andreas Palagyi, Kornelia Neveling, Ursula Plinninger, Andreas Ziesch, Bianca-Sabrina Targosz, Gerald U Denk, Stephanie Ochs, Antonia Rizzani, Daniel Meier, Wolfgang E Thasler, Helmut Hanenberg, Enrico N De Toni, Florian Bassermann, Claus Schäfer, Burkhard Göke, Detlev Schindler…
    Citation: Molecular Cancer 2010 9:127
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    37.3 - 2-year Impact Factor
    33.1 - 5-year Impact Factor
    5.740 - SNIP (Source Normalized Impact per Paper)
    8.703 - SJR (SCImago Journal Rank)

    2023 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    91 days submission to accept (Median)

    2023 Usage 
    3,569,666 downloads
    2,070 Altmetric mentions 

Follow

Molecular Cancer

ISSN: 1476-4598