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  1. Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to...

    Authors: Xin Lian, Kailin Yang, Renliang Li, Maomao Li, Jing Zuo, Bohao Zheng, Wei Wang, Ping Wang and Shengtao Zhou

    Citation: Molecular Cancer 2022 21:27

    Content type: Review

    Published on:

  2. Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is necessary to find new tumor markers...

    Authors: Wen Li, Ji-Bin Liu, Li-Kun Hou, Fei Yu, Jie Zhang, Wei Wu, Xiao-Mei Tang, Feng Sun, Hai-Min Lu, Jing Deng, Jie Bai, Juan Li, Chun-Yan Wu, Qin-Lu Lin, Zhong-Wei Lv, Gao-Ren Wang…

    Citation: Molecular Cancer 2022 21:25

    Content type: Review

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  3. Cancer-associated fibroblasts (CAFs) are critically involved in gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which CAFs promote chemotherapy res...

    Authors: Chonghui Hu, Renpeng Xia, Xiang Zhang, Tingting Li, Yuancheng Ye, Guolin Li, Rihua He, Zhihua Li, Qing Lin, Shangyou Zheng and Rufu Chen

    Citation: Molecular Cancer 2022 21:24

    Content type: Research

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  4. Functions of CircMET (hsa_circ_0082002) which is a circular RNA and derived from MET gene remain understood incompletely. In the present study, Xp11.2 translocation/NONO-TFE3 fusion renal cell carcinoma (NONO-TFE...

    Authors: Lei Yang, Yi Chen, Ning Liu, Yanwen Lu, Wenliang Ma, Zhenhao Yang, Weidong Gan and Dongmei Li

    Citation: Molecular Cancer 2022 21:23

    Content type: Research

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  5. The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-dependent manner in responses to variety of stresses that are common in cancers. We focus on a cancer-enriched tsRNA signature to develop a saliv...

    Authors: Kai Li, Yusheng Lin, Yichen Luo, Xiao Xiong, Lu Wang, Kameron Durante, Junkuo Li, Fuyou Zhou, Yi Guo, Shaobin Chen, Yuping Chen, Dianzheng Zhang, Sai-Ching Jim Yeung and Hao Zhang

    Citation: Molecular Cancer 2022 21:21

    Content type: Research

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  6. The immunotherapy with immune checkpoints inhibitors (ICI) has changed the life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not respond hence, the identification and vali...

    Authors: Simona Serratì, Michele Guida, Roberta Di Fonte, Simona De Summa, Sabino Strippoli, Rosa Maria Iacobazzi, Alessandra Quarta, Ivana De Risi, Gabriella Guida, Angelo Paradiso, Letizia Porcelli and Amalia Azzariti

    Citation: Molecular Cancer 2022 21:20

    Content type: Research

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  7. Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective pressure, tumor cells show various adaptive characteristics, such as changes in the expression of cancer hallmarks (incr...

    Authors: Guangpeng He, Xueqiang Peng, Shibo Wei, Shuo Yang, Xinyu Li, Mingyao Huang, Shilei Tang, Hongyuan Jin, Jiaxing Liu, Sheng Zhang, Hongyu Zheng, Qing Fan, Jingang Liu, Liang Yang and Hangyu Li

    Citation: Molecular Cancer 2022 21:19

    Content type: Review

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  8. Considerable evidence shows that circular RNAs (circRNAs) play an important role in tumor development. However, their function in intrahepatic cholangiocarcinoma (ICC) metastasis and the underlying mechanisms ...

    Authors: Jinpeng Du, Tian Lan, Haotian Liao, Xuping Feng, Xing Chen, Wenwei Liao, Guimin Hou, Lin Xu, Qingbo Feng, Kunlin Xie, Mingheng Liao, Xiangzheng Chen, Jiwei Huang, Kefei Yuan and Yong Zeng

    Citation: Molecular Cancer 2022 21:18

    Content type: Research

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  9. miRNAs are regulatory transcripts established as repressors of mRNA stability and translation that have been functionally implicated in carcinogenesis. miR-10b is one of the key onco-miRs associated with multi...

    Authors: Rachid El Fatimy, Yanhong Zhang, Evgeny Deforzh, Mahalakshmi Ramadas, Harini Saravanan, Zhiyun Wei, Rosalia Rabinovsky, Nadiya M. Teplyuk, Erik J. Uhlmann and Anna M. Krichevsky

    Citation: Molecular Cancer 2022 21:17

    Content type: Research

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  10. Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), a newly found type of endogenous noncoding...

    Authors: Ziwen Pan, Rongrong Zhao, Boyan Li, Yanhua Qi, Wei Qiu, Qindong Guo, Shouji Zhang, Shulin Zhao, Hao Xu, Ming Li, Zijie Gao, Yang Fan, Jianye Xu, Huizhi Wang, Shaobo Wang, Jiawei Qiu…

    Citation: Molecular Cancer 2022 21:16

    Content type: Research

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  11. Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of...

    Authors: Reza Hosseini, Hamzeh Sarvnaz, Maedeh Arabpour, Samira Molaei Ramshe, Leila Asef-Kabiri, Hassan Yousefi, Mohammad Esmaeil Akbari and Nahid Eskandari

    Citation: Molecular Cancer 2022 21:15

    Content type: Review

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  12. Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of ti...

    Authors: Yuanyuan An and Hua Duan

    Citation: Molecular Cancer 2022 21:14

    Content type: Review

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  13. Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation. However, increasing numbers of translated c...

    Authors: Yan Wang, Chunjie Wu, Yu Du, Zhongwei Li, Minle Li, Pingfu Hou, Zhigang Shen, Sufang Chu, Junnian Zheng and Jin Bai

    Citation: Molecular Cancer 2022 21:13

    Content type: Review

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  14. More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely u...

    Authors: Yu-Zhong Yu, Dao-Jun Lv, Chong Wang, Xian-Lu Song, Tao Xie, Tao Wang, Zhi-Min Li, Jia-Ding Guo, Du-Jiang Fu, Kang-Jin Li, Ding-Lan Wu, Franky Leung Chan, Ning-Han Feng, Zhe-Sheng Chen and Shan-Chao Zhao

    Citation: Molecular Cancer 2022 21:12

    Content type: Research

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  15. Hepatocellular carcinoma (HCC) is among the most common forms of cancer and is associated with poor patient outcomes. The emergence of therapeutic resistance has hampered the efficacy of targeted treatments em...

    Authors: Yiran Chen, Li Li, Jie Lan, Yang Cui, Xiaosong Rao, Jing Zhao, Tao Xing, Gaoda Ju, Guangtao Song, Jizhong Lou and Jun Liang

    Citation: Molecular Cancer 2022 21:11

    Content type: Research

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  16. Circular RNAs (circRNAs) play important roles in many biological processes. However, the detailed mechanism underlying the critical roles of circRNAs in cancer remains largely unexplored. We aim to explore the...

    Authors: Chi Hin Wong, Ut Kei Lou, Frederic Khe-Cheong Fung, Joanna H. M. Tong, Chang-hua Zhang, Ka-Fai To, Stephen Lam Chan and Yangchao Chen

    Citation: Molecular Cancer 2022 21:10

    Content type: Research

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  17. Approximate 25% HER2-positive (HER2+) breast cancer (BC) patients treated with trastuzumab recurred rapidly. However, the mechanisms underlying trastuzumab resistance remained largely unclear.

    Authors: Yun Ling, Gehao Liang, Qun Lin, Xiaolin Fang, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Zihao Liu, Yu Shi, Juanmei Li, Wanyi Lin, Shijie Jia, Wenqian Yang, Qiang Liu, Erwei Song…

    Citation: Molecular Cancer 2022 21:8

    Content type: Research

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  18. Authors: Thomas Dillinger, Raheleh Sheibani-Tezerji, Walter Pulverer, Ines Stelzer, Melanie R. Hassler, Janine Scheibelreiter, Carlos Uziel Pérez Malla, Madeleine Kuroll, Sandra Domazet, Elisa Redl, Sarah Ely, Stefanie Brezina, Andreas Tiefenbacher, Katharina Rebhan, Nicolai Hübner, Bernhard Grubmüller…

    Citation: Molecular Cancer 2022 21:7

    Content type: Letter to the Editor

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  19. Dysregulation of long noncoding RNAs (lncRNAs) has been linked to various human cancers. Bcr-Abl oncogene that results from a reciprocal translocation between human chromosome 9 and 22, is associated with several...

    Authors: Yun Ma, Guijie Guo, Tingting Li, Faxin Wen, Jianling Yang, Biao Chen, Xuefei Wang and Ji-Long Chen

    Citation: Molecular Cancer 2022 21:5

    Content type: Research

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  20. Camrelizumab plus chemotherapy significantly prolonged progression-free survival (PFS) and overall survival (OS) compared to chemotherapy alone as first-line treatment in advanced lung squamous cell carcinoma ...

    Authors: Tao Jiang, Jianhua Chen, Xingxiang Xu, Ying Cheng, Gongyan Chen, Yueyin Pan, Yong Fang, Qiming Wang, Yunchao Huang, Wenxiu Yao, Rui Wang, Xingya Li, Wei Zhang, Yanjun Zhang, Sheng Hu, Renhua Guo…

    Citation: Molecular Cancer 2022 21:4

    Content type: Research

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wei Wang, Wentao Hu, Ya Wang, Yong An, Lei Song, Panfeng Shang and Zhongjin Yue

    Citation: Molecular Cancer 2022 21:3

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2020 19:18

  22. Authors: Florencia Cidre-Aranaz, Jing Li, Tilman L. B. Hölting, Martin F. Orth, Roland Imle, Stefanie Kutschmann, Giulia Ammirati, Katharina Ceranski, Martha Julia Carreño-Gonzalez, Merve Kasan, Aruna Marchetto, Cornelius M. Funk, Felix Bestvater, Simone Bersini, Chiara Arrigoni, Matteo Moretti…

    Citation: Molecular Cancer 2022 21:1

    Content type: Letter to the Editor

    Published on:

  23. In recent years, the application of functional genetic immuno-oncology screens has showcased the striking ability to identify potential regulators engaged in tumor-immune interactions. Although these screens h...

    Authors: Yan Li, Chen Yang, Zhicheng Liu, Shangce Du, Susan Can, Hailin Zhang, Linmeng Zhang, Xiaowen Huang, Zhenyu Xiao, Xiaobo Li, Jingyuan Fang, Wenxin Qin, Chong Sun, Cun Wang, Jun Chen and Huimin Chen

    Citation: Molecular Cancer 2022 21:2

    Content type: Research

    Published on:

  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao and Jingxuan Pan

    Citation: Molecular Cancer 2021 20:172

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2010 9:112

  25. Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also in the activation, differentiation and effector function(s) of immune cells. In this review, we summarize current ...

    Authors: Enyong Dai, Zhi Zhu, Shudipto Wahed, Zhaoxia Qu, Walter J. Storkus and Zong Sheng Guo

    Citation: Molecular Cancer 2021 20:171

    Content type: Review

    Published on:

  26. Recent studies have revealed the significant dysregulation of m6A level in peripheral blood in several cancer types and its value in diagnosis. Nonetheless, a biomarker for accurate screening of multiple cancer t...

    Authors: Bo Zhang, Zhenmei Chen, Baorui Tao, Chenhe Yi, Zhifei Lin, Yitong Li, Weiqing Shao, Jing Lin and Jinhong Chen

    Citation: Molecular Cancer 2021 20:170

    Content type: Letter to the Editor

    Published on:

  27. Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression, generally acting as microRNA (miRNA) sponges to regulate downstream gene expression. Howeve...

    Authors: Cheng-Peng Gui, Bing Liao, Cheng-Gong Luo, Yu-Hang Chen, Lei Tan, Yi-Ming Tang, Jia-Ying Li, Yi Hou, Hong-De Song, Hai-Shan Lin, Quan-Hui Xu, Gao-Sheng Yao, Hao-Hua Yao, Xi-Liu, Jun-Hang Luo, Jia-Zheng Cao…

    Citation: Molecular Cancer 2021 20:169

    Content type: Research

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  28. Craniopharyngioma (CP) is rare histologically benign but clinically challenging tumor because of its intimate relationship with the critical structure in the central brain. CP can be divided into two major his...

    Authors: Juan He, Zhen Zeng, Yuelong Wang, Jiaojiao Deng, Xin Tang, Fujun Liu, Jianhan Huang, Hongxu Chen, Ruichao Liang, Xin Zan, Zhiyong Liu, Aiping Tong, Gang Guo, Jianguo Xu, Xiaofeng Zhu, Liangxue Zhou…

    Citation: Molecular Cancer 2021 20:168

    Content type: Research

    Published on:

  29. Accumulating studies have revealed that aberrant expression of circular RNAs (circRNAs) is widely involved in the tumorigenesis and progression of malignant cancers, including colorectal cancer (CRC). Neverthe...

    Authors: Tao Jiang, Hongyu Wang, Lianyu Liu, Hu Song, Yi Zhang, Jiaqi Wang, Lei Liu, Teng Xu, Ruizhi Fan, Yixin Xu, Shuai Wang, Linsen Shi, Li Zheng, Renhao Wang and Jun Song

    Citation: Molecular Cancer 2021 20:167

    Content type: Research

    Published on:

  30. Dysregulation of circular RNAs (circRNAs) plays an important role in the development of gastric cancer; thus, revealing the biological and molecular mechanisms of abnormally expressed circRNAs is critical for ...

    Authors: Dong-Liang Chen, Hui Sheng, Dong-Sheng Zhang, Ying Jin, Bai-Tian Zhao, Nuo Chen, Kang Song and Rui-Hua Xu

    Citation: Molecular Cancer 2021 20:166

    Content type: Research

    Published on:

  31. Stem Cell leukemia/lymphoma syndrome (SCLL) presents as a myeloproliferative disease which can progress to acute myeloid leukemia and is associated with the coincident development of B-cell and T-cell lymphoma...

    Authors: Baohuan Cai, Yun Liu, Yating Chong, Hualei Zhang, Atsuko Matsunaga, Xuexiu Fang, Rafal Pacholczyk, Gang Zhou, John K. Cowell and Tianxiang Hu

    Citation: Molecular Cancer 2021 20:165

    Content type: Research

    Published on:

  32. Clinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma (HCC) patients after radical surgery are extremely limited. Neoantigen based vaccine can generate robust anti-tumor immune respo...

    Authors: Zhixiong Cai, Xiaoping Su, Liman Qiu, Zhenli Li, Xiaolou Li, Xiuqing Dong, Fuqun Wei, Yang Zhou, Liuping Luo, Geng Chen, Hengkai Chen, Yingchao Wang, Yongyi Zeng and Xiaolong Liu

    Citation: Molecular Cancer 2021 20:164

    Content type: Research

    Published on:

  33. Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often associated with the pathogenesi...

    Authors: Yu Wang, Jiang Du, Xuemei Wu, Ahmed Abdelrehem, Yu Ren, Chao Liu, Xuan Zhou and Sinan Wang

    Citation: Molecular Cancer 2021 20:163

    Content type: Review

    Published on:

  34. Cis-diamminedichloro-platinum (CDDP)-based chemotherapy regimens are the most predominant treatment strategies for patients with esophageal squamous cell carcinoma (ESCC). Dysregulated long non-coding RNAs (ln...

    Authors: Yunlong Jia, Cong Tian, Hongyan Wang, Fan Yu, Wei Lv, Yuqing Duan, Zishuo Cheng, Xuexiao Wang, Yu Wang, Tianxu Liu, Jiali Wang and Lihua Liu

    Citation: Molecular Cancer 2021 20:162

    Content type: Research

    Published on:

  35. Circular RNAs (circRNAs), a class of noncoding RNAs (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. Howe...

    Authors: Shenglong Li, Fei Liu, Ke Zheng, Wei Wang, Enduo Qiu, Yi Pei, Shuang Wang, Jiaming Zhang and Xiaojing Zhang

    Citation: Molecular Cancer 2021 20:161

    Content type: Research

    Published on:

  36. Prostate adenocarcinoma (PRAD) is a leading cause of death among men. Messenger ribonucleic acid (mRNA) vaccine presents an attractive approach to achieve satisfactory outcomes; however, tumor antigen screenin...

    Authors: Xiaonan Zheng, Hang Xu, Xianyanling Yi, Tianyi Zhang, Qiang Wei, Hong Li and Jianzhong Ai

    Citation: Molecular Cancer 2021 20:160

    Content type: Letter to the Editor

    Published on:

  37. Current treatment strategy for kidney renal clear cell carcinoma (KIRC) is limited. Tumor-associated antigens, especially neoantigen-based personalized mRNA vaccines represent new strategies and manifest clini...

    Authors: Hang Xu, Xiaonan Zheng, Shiyu Zhang, Xianyanling Yi, Tianyi Zhang, Qiang Wei, Hong Li and Jianzhong Ai

    Citation: Molecular Cancer 2021 20:159

    Content type: Letter to the Editor

    Published on:

  38. Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a microRNA sponge or a scaffold to interact with p...

    Authors: Yin Peng, Yidan Xu, Xiaojing Zhang, Shiqi Deng, Yuan Yuan, Xiaonuan Luo, Md Tofazzal Hossain, Xiaohui Zhu, Kaining Du, Fan Hu, Yang Chen, Shanshan Chang, Xianling Feng, Xinmin Fan, Hassan Ashktorab, Duane Smoot…

    Citation: Molecular Cancer 2021 20:158

    Content type: Research

    Published on:

  39. Non-small cell lung cancer (NSCLC) is the most common type of human lung cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play imp...

    Authors: Yaomei He, Xiulin Jiang, Lincan Duan, Qiuxia Xiong, Yixiao Yuan, Peishen Liu, Liping Jiang, Qiushuo Shen, Song Zhao, Cuiping Yang and Yongbin Chen

    Citation: Molecular Cancer 2021 20:156

    Content type: Research

    Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weipu Mao, Keyi Wang, Bin Xu, Hui Zhang, Si Sun, Qiang Hu, Lei Zhang, Chunhui Liu, Shuqiu Chen, Jianping Wu, Ming Chen, Wei Li and Bo Peng

    Citation: Molecular Cancer 2021 20:155

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2021 20:142

  41. To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years in particular with the advent of clinical successes achieved by targeting immune checkpoint ...

    Authors: Chao Li, Adilson Fonseca Teixeira, Hong-Jian Zhu and Peter ten Dijke

    Citation: Molecular Cancer 2021 20:154

    Content type: Review

    Published on:

  42. Epstein-Barr virus (EBV) represents an important pathogenic factor of lymphoma and is significantly associated with poor clinical outcome of diffuse large B-cell lymphoma (DLBCL). Circular RNAs (circRNAs) play...

    Authors: Chen-xing Zhao, Zi-xun Yan, Jing-jing Wen, Di Fu, Peng-peng Xu, Li Wang, Shu Cheng, Jian-da Hu and Wei-li Zhao

    Citation: Molecular Cancer 2021 20:153

    Content type: Research

    Published on:

  43. Authors: Matteo Allegretti, Alessandra Fabi, Elena Giordani, Cristiana Ercolani, Paolo Romania, Cecilia Nisticò, Simona Gasparro, Vittoria Barberi, Maria Ciolina, Edoardo Pescarmona, Diana Giannarelli, Gennaro Ciliberto, Francesco Cognetti and Patrizio Giacomini

    Citation: Molecular Cancer 2021 20:151

    Content type: Letter to the Editor

    Published on:

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