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Fig. 8 | Molecular Cancer

Fig. 8

From: Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer

Fig. 8

RBM15 and IGF2BPs significantly inhibited cell proliferation in prostate cancer. A Endogenous IGF2BPs and RBM15 mRNA levels in different human PCa cell lines. Data are presented as means ± SD, two-tailed unpaired t-test. B IGF2BP proteins were determined in PCa samples and paired adjacent normal tissues. Data are presented as means ± SD, two-tailed unpaired t-test. C IGF2BPs and RBM15 protein levels are markedly decreased in human PCa cell lines compared to RWPE-1 cell lines. (A). Endogenous IGF2BPs mRNA levels in different human PCa cell lines. D-E Typical tumor-bearing nude mice after 5 weeks (D), the tumor weight and volume (E) of 5 groups injected with same number of PC-3 tumor cells in nude mice after various treatment for 5 weeks (n = 5), Data are presented as means ± SD, two-tailed unpaired t-test. D IGF2BPs and RBM15 protein levels are markedly decreased in human PCa cell lines compared to RWPE-1 cell lines. F-G Overexpression of RBM15 and IGF2BP proteins significantly inhibited the cell proliferation in DU-145 and PC-3 cells. Data are presented as means ± SD, two-tailed unpaired t-test

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Molecular Cancer

ISSN: 1476-4598