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Fig. 2 | Molecular Cancer

Fig. 2

From: Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Fig. 2

Comparison of the proportions of adaptive and innate immune cells in TC-1 tumor bearing mice induced by plasmid vector (vehicle), E6E7 and CCL11-E6E7 vaccination for once (n = 7 for each group). A Bar graphs (mean ± SEM) show the percentage of E7 tetramer + cells of CD8 + T cells from blood, spleen and lymph node in each group. B-K The tumor was removed and digested into single cell suspension for FACS analysis of adaptive and innate immune cells. Scatter plots (mean ± SEM) show the percentage of (B) CD8 + E7 tetramer + of CD45 + cells. C-K Scatter plots (mean ± SEM) show the percentage of (C) CD45 + cells, (D) CD8 + cells, (E) CD4 + cells of viable cells (F) Treg cells, (G) NK cells, (H) NKT cells, (I) M1 macrophage, (J) M2 macrophage, (K) MDSC cells and. L, Scatter plots (mean ± SEM) show the ratio of CD8/MDSC cells. Statistical significance was calculated using a student's t-test, where "ns" stands for not significant

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Molecular Cancer

ISSN: 1476-4598