JAK/STAT mutations and resulting disorders | |||
---|---|---|---|
JAK/STAT | Mutation | Disease | Reference |
JAK1 | S703I | ALL | [59] |
T478S | AML | [60] | |
V623A | AML | [60] | |
JAK2 | JAK2/REED | AML | [61] |
V617F | AML | [62] | |
K607N | AML | [63] | |
T875N | AML | [64] | |
JAK3 | A572VV722IP132T | AMKL | [62] |
M511I | PLL | [65] | |
V722I | AMKL | [66] | |
A572V | AMKL | [66] | |
P132T | AMKL | [66] | |
STAT3 | Y640F | LGLL | [67] |
D661Y | LGLL | [67] | |
D661V | LGLL | [67] | |
N647I | LGLL | [67] | |
ATL | [68] | ||
T-LGLL | [69] | ||
AML | |||
STAT5 | CML | ||
AML | |||
Ph + ALL | [76] | ||
B-ALL | [77] | ||
STAT5a | TCL | [78] | |
STAT5b | T-PLL | [79] | |
Y665F | LGLL | [80] | |
N642H | LGLL、TCL | [81] | |
N642H | T-ALL | [82] |