From: CDK5: an oncogene or an anti-oncogene: location location location
No | Substrate | Cancer Types | Phosphorylation sites | Protein type | Function | References |
---|---|---|---|---|---|---|
1 | FAK | Breast cancer | S732 | Kinase | Chemotaxis and invasion | [42] |
2 | PPARγ | Breast cancer | S273 | Transcription factor | Metastasis and stemness | [43] |
3 | ADD1 | Breast cancer | T724 | Actin-binding protein | Cell migration and invasion | [44] |
4 | Talin | Breast cancer | S425 | Cytoskeletal protein | Migration | [45] |
5 | PIPKIγ90 | Breast cancer | S453 | Kinase | Chemotaxis and invasion | [46] |
6 | FOXO1 | Breast cancer | S249 | Transcription factor | Inhibits apoptosis | [49] |
7 | AR | Prostate cancer | S81 | Transcription factor | Proliferation | [50] |
8 | AR | Prostate cancer | S308 | Transcription factor | Unknown | [54] |
9 | STAT3 | Prostate cancer | S727 | Transcription factor | Proliferation | [55] |
10 | p21CIP | Prostate cancer | S130 | CDK inhibitor | Proliferation | [56] |
11 | Talin 1 (Talin) | Prostate cancer | S425 | Cytoskeletal protein | Invasion | [57] |
12 | Rb | Prostate cancer | S807, S811 | Tumor suppressor | Neuroendocrine Differentiation | [58] |
13 | EZH2 | Pancreatic Cancer | T261 | Histone-lysine N-methyltransferase | Inhibits migration and invasion | [61] |
14 | Rb | MTC | S807, S811 | Tumor suppressor | Proliferation | [34] |
15 | STAT3 | MTC | S727 | Transcription factor | Proliferation and Tumorigenesis | |
16 | ERK5 | Colorectal cancer | T732 | Kinase | Proliferation | [66] |
17 | CRMP-2 | Glioblastoma | S522 | Axonal growth and guidance protein | Proliferation | [70] |
18 | PIKE-A | Glioblastoma | S249, S279 | GTPase | Proliferation and migration | [71] |
19 | TRIM59 | Glioblastoma | S308 | E3 ubiquitin ligase | Tumorigenesis | [72] |
20 | Cortactin | Glioblastoma | T145, T219 | F-actin-binding protein | Migration | [73] |
21 | ACSS2 | Glioblastoma | S267 | Metabolic enzyme | Tumorigenesis | [74] |
22 | DRP1 | Glioblastoma | S616 | GTPase | Mitochondrial fission | [76] |
23 | TPX2 | HCC | S486 | Spindle assembly factors | Protein stability and metastasis | [80] |
23 | HIF-1α | HCC | S687 | Hypoxia inducible factors | Angiogenesis | [83] |
24 | PRMT1 | HCC | S307 | Arginine methyltransferase | Tumorigenesis | [84] |
25 | VEGFR2 | Pituitary Adenoma | S229 | Tyrosine kinase receptor | Invasion and metastasis | [86] |
26 | CAP1 | Lung cancer | S308 and S310 | Actin-binding protein | Proliferation, migration and invasion | |
27 | DLC-1 | Lung cancer | S120, S205, S422, S509 | Tumor suppressor | Inhibits tumorigenesis | [96] |
28 | Vimentin | Melanoma | S56 | Cytoskeletal protein | Invasion and metastasis | [101] |
29 | NOXA | Leukemia | S13 | Pro-apoptotic factor | Proliferation and survival | [112] |