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Fig. 4 | Molecular Cancer

Fig. 4

From: Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment

Fig. 4

Effect of CAFs on TME through paracrine signaling. a GO enrichmet of ligands from mCAFs to endothelial cells. b GO enrichmet of ligands from iCAFs to macrophages. c GO enrichmet of ligands from iCAFs to CD8 + T cells. d Integrated ranking of LRIs based on number of LRIs from mCAFs to endothelial cells using RRA algorithm across 22 tissue slices. e Integrated ranking of LRIs based on number of LRIs from iCAFs to macrophages using RRA algorithm across 22 tissue slices. f Integrated ranking of LRIs based on number of LRIs from iCAFs to CD8 + T cells using RRA algorithm across 22 tissue slices. g Spatial distribution of the LGALS1-PTPRC interaction on two spatial transcriptomics tissue slices (BRCA0 and LIHC1). h Representative immunofluorescence images of CFD (red) and CD8 (green) in tissues from three patients with BRCA and three patients with LIHC. Scale bar represents 20 μm

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Molecular Cancer

ISSN: 1476-4598