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Fig. 2 | Molecular Cancer

Fig. 2

From: Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment

Fig. 2

CAF heterogeneity in pan-cancer. a UMAP plots showing the integration of fibroblasts across six different cancer types by Harmony. b Differential expression analysis showing the upregulated genes for each fibroblast subtype. An adjusted p value < 0.05 is indicated in red, while an adjusted p value ≥ 0.05 is indicated in blue. c GO enrichment analysis of upregulated genes in each CAF subtype. d Heatmap showing pathway activities scored by AUCell in each CAF subtype. e Proportion of CAF subtypes across multiple cancer types. f Heatmap showing the ORs of CAF subtypes in each cancer type. g Scatter plot showing the RSSs in each CAF subtype. The top 5 regulons are highlighted. h SCAP analysis of metabolic pathways in meCAFs. i Slingshot trajectory analysis of CAFs. j GeneSwitches analysis of pathway activity changes in the transition pathway from pericytes to iCAFs

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Molecular Cancer

ISSN: 1476-4598