Fig. 1
From: Profiling small RNAs in fecal immunochemical tests: is it possible?
A. Graphical representation of the study. B. Principal component analysis (PCA) of samples based on mature miRNA read counts. C. Bar plot reporting, for each cohort and sample type, the average levels of the miRNAs associated with the highest levels in MITOS-FIT leftover samples. D. Mean normalised abundance of miRNAs in paired MITOS-FIT (x-axis) and MITOS-Stool (y-axis) samples. Each point represents a miRNA coloured based on the Spearman correlation coefficient for comparison of paired samples. Only miRNAs detected in at least 15% of each sample type were included in this analysis. E. Scatterplot showing the log2FC of expression computed considering MITOS-stool (x-axis) and MITOS-FIT leftover (y-axis) miRNA levels in samples from CRC patients with respect to those from colonoscopy-negative subjects. F. Heatmap of the Z-score normalised miRNA levels in MITOS-stool and MITOS-FIT leftover samples. AA, advanced adenoma; nAA, non-advanced adenoma; CRC, colorectal cancer