Fig. 4From: The strategies to cure cancer patients by eradicating cancer stem-like cellsTME-induced immunosuppressive environment for the maintenance of CSC properties. Cytokines and growth factors from CAFs, Tregs, MDSCs and TAMs activate cancer-related EMT and suppress DC cell maturation, NK cell function, and TH1/TH2 differentiation. Additionally, TME-derived factors activate cancer-associated pathways including PI3K/Akt, JAK/STAT, and RASBack to article page