Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi, Mohammad; Chehelgerdi, Matin; Allela, Omer Qutaiba B.; Pecho, Renzon Daniel Cosme; Jayasankar, Narayanan; Rao, Devendra Pratap; Thamaraikani, Tamilanban; Vasanthan, Manimaran; Viktor, Patrik; Lakshmaiya, Natrayan; Saadh, Mohamed J.; Amajd, Ayesha; Abo-Zaid, Mabrouk A.; Castillo-Acobo, Roxana Yolanda; Ismail, Ahmed H.; Amin, Ali H.; Akhavan-Sigari, Reza

doi:10.1186/s12943-023-01865-0

Molecular Cancer

Table 8 Pharmacokinetic profiles of nanocarrier-loaded drugs

From: Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Drug Type	Administration Route	Pharmacokinetic Parameter	Clearance Pathway	Drug Interaction	Therapeutic Window	References
Doxorubicin	Intravenous	Area Under Curve (AUC)	Hepatic Metabolism	P-glycoprotein	Narrow	[201]
Paclitaxel	Intravenous	Half-life	Renal Excretion	Cytochrome P450	Wide	[57]
Cisplatin	Intraperitoneal	Volume of Distribution	Renal Excretion	None	Narrow	[90, 102]
Irinotecan	Oral	Bioavailability	Hepatic Metabolism	UDP-glucuronosyltransferase	Wide	[202]
Methotrexate	Intrathecal	Cerebrospinal Fluid Concentration	Renal Excretion	None	Narrow	[99]
Gemcitabine	Intravenous	Clearance Rate	Renal Excretion	Deoxycytidine Kinase	Wide	[203]
Etoposide	Intravenous	Distribution Half-life	Hepatic Metabolism	Cytochrome P450	Wide	[204]
Oxaliplatin	Intravenous	Total Clearance	Renal Excretion	None	Narrow	[205]
Topotecan	Oral	Bioavailability	Hepatic Metabolism	Cytochrome P450	Narrow	[206]
Docetaxel	Intravenous	Protein Binding	Hepatic Metabolism	P-glycoprotein	Wide	[207]
Methotrexate	Intravenous	Clearance	Renal Excretion	None	Narrow	[208]
Trastuzumab	Intravenous	Volume of Distribution	Proteolysis	None	Wide	[189]
Docetaxel	Intravenous	Protein Binding	Hepatic Metabolism	P-glycoprotein	Wide	[117]
Bleomycin	Intravenous	Half-life	Renal Excretion	None	Narrow	[209]
Vinorelbine	Oral	Bioavailability	Hepatic Metabolism	P-glycoprotein	Wide	[210]
Daunorubicin	Intravenous	AUC	Hepatic Metabolism	P-glycoprotein	Narrow	[211]
Cisplatin	Intravenous	Half-life	Renal Excretion	None	Narrow	[212]
Pemetrexed	Intravenous	Protein Binding	Renal Excretion	None	Narrow	[213]
Everolimus	Oral	Bioavailability	Hepatic Metabolism	Cytochrome P450	Wide	[214]
Tamoxifen	Oral	Clearance	Hepatic Metabolism	None	Wide	[215]

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ISSN: 1476-4598

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