Fig. 16

The utilization of layered double hydroxides to control the release of drugs in both in vitro and in vivo settings and their consequent effects. A In vitro drug release profiles for three different drugs intercalated LDHs- nitrate, carbonate, and phosphate (LN-R, LC-R, and LP-R respectively) are displayed, along with an inset figure showcasing their release pattern within the first 8 h. B The cytotoxicity of the free drug and drug intercalated LDHs against HeLa cells at various time intervals is demonstrated. C The antitumor effect and systematic toxicity of pure RH and drug intercalated LDHs are shown in comparison to the control group in an in vivo setting. D Finally, the histological analysis of liver, kidney, and spleen of tumor-bearing mice treated with control (saline), pure RH, LN-R, and LP-R are illustrated. Reprint from [180] with a permission from Springer Nature