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Fig. 9 | Molecular Cancer

Fig. 9

From: Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency

Fig. 9

Schematic representation of the methodology, clinical relevance, underlying mechanisms, and therapeutic implications presented in this study. We uncovered intricate interactions between Wnt and YAP signaling, regulated by RASA1 and NF2 deficiency in CSC biology. Our findings spotlight a novel therapeutic strategy: the inhibition of Bcl-2 family members and YAP signaling, potentially inducing synthetic lethality, particularly in NF2 and RASA1 deficient cases. This strategy opens up a potential path to counter drug resistance in highly metastatic GC

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Molecular Cancer

ISSN: 1476-4598