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Fig. 4 | Molecular Cancer

Fig. 4

From: CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer

Fig. 4

CircXRN2 is a negative regulator of glycolysis in human bladder cancer cells. a Control or circXRN2-overexpressing bladder cancer cells were incubated with 2-NBDG (a fluorescent D-glucose analog) and subjected to flow cytometry to monitor glucose uptake. b Overexpression of circXRN2 decreased the uptake of glucose in T24 and TCCSUP cells. c Lactate production was suppressed in the presence of circXRN2. d Seahorse metabolic analysis showed that circXRN2 significantly inhibited glycolysis in bladder cancer cells, which was marked by a decreased glycoPER (glycolytic proton efflux rate), basal glycolysis rate and compensatory glycolysis rate. All the data are presented as the mean ± standard deviation (n = 3). *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598