Table 5 Elaboration of antitumor effects of cannabinoids on melanoma and nonmelanoma skin cancer
Cannabinoid Type Tested | Cancer Cell Line Tested | Results |
|---|---|---|
D (9)-tetrahydrocannabinol | BRAF wild-type melanoma cell line CHL-1 BRAF-mutated A375 and SK-MEL-28 melanoma cell lines | Activation of autophagy and apoptosis, loss of cell viability |
JWH-133 synthetic cannabinoid | Human melanoma cell line A2058 | Activation of CB2 receptors with JWH-133 reduced adhesion of melanoma cells to brain endothelial cells and decreased trans-endothelial migration rate of melanoma cells |
THC WIN-55,212–2 | Murine melanoma cell line B16 Human melanoma cell line Meljuso | Decreased melanoma cell viability and increased apoptosis in vitro. Decreased tumor cell growth, proliferation, angiogenesis, and metastasis in vivo |