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Fig. 1 | Molecular Cancer

Fig. 1

From: Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade

Fig. 1

Schematic representation of Adhesion-to-suspension transition (AST) in vitro. Ectopic expression of the four hematopoietic factors IKZF1, NFE2, BTG2, IRF8 in adherent cell lines is sufficient to induce adhesion-to-suspension transition (AST), promoting anchorage-independent growth in vitro. AST induction leads to YAP/TEAD-dependent loss of cell-matrix interaction and confers resistance to anoikis achieved through HBA1/2-mediated suppression of lethal reactive oxygen species (ROS). Figure is created in “BioRender.com”

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Molecular Cancer

ISSN: 1476-4598