Table 4 Application of LPHNPs in lung cancer therapeutics

1

HSPC, DSPE-PEG-2000, DOTAP, DPPC and 1- palmitoyl-2-[6-[(7-nitro-2–1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3- phosphocholine

PCL

_

Erlotinib

A549 cells

_

[253]

2

Soybean lecithin SL-100 M and DSPE-PEG 2000

PLGA

_

HCPT

MCF-7

Kunming mice

[254]

3

DSPE-mPEG

amphiphilic polymer poly(ethylene glycol) methyl ether-grafted disulfide-poly(β-amino esters)

_

DOX

Lewis lung cancer cells

_

[255]

4

DSPE-mPEG₅₀₀₀ and soybean lecithin

PLGA

_

PTX and triptolide

A549

Balb/c-nude mice

[135]

5

3′-Dithiodipropionic acid,

PLGA

RGD

PTX and CPT

A549

Balb/c-nude mice

[256]

6

DSPE-PEG-2000-maleimide

PLA

EGFR ligand

CPT and DOX

A549

Male C57BL/6 mice

[257]

7

DOTAP

PLGA

_

Anti-inflammatory microRNA

Bronchial epithelial cells

_

[258]

8

DSPC-PEG-2000, Lecithin soybean and tristearin

PLGA

_

CD47 siRNA and etoposode

B16F10

[259]

9

Cholesterol-PEG

PLGA

Transferrin

Afatinib

H1975, PC-9

Balb/c-nude mice

[260]

10

CHO-PEG-NH2, SPC

Polycaprolactone (PCL)

Hyaluronic acid

Erlotinib and bevacizumab

A549, H1975 cells

Balb/c-nude mice

[261]