Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Table 1 LPHNPs in breast cancer therapy

Sr. No	Lipid component	Polymer component	Targeting moiety	Drug	In vitro	In vivo	Ref
1	DSPE-PEG-2000	PLGA	_	DTX	MDA-MB-231	Female Balb/c mice	[179]
2	SPC and DSPE-PEG	PLGA	_	GEM	_	_	[139]
3	SPC and DSPE-PEG-2000	PLGA	_	GEM	MCF-7 and MDA-MB-231	Sprague–Dawley rats	[180]
4	Lipoid S100	PLGA	_	MTX	MDA-MB-231	_	[50]
5	lecithin with DSPE-PEG-2000	PLGA	_	SFN	MDA-MB-231	_	[181]
6	Soybean phospholipid and DEPE-PEG-2000	PLGA	_	Emodin	MCF-7/ADR	_	[182]
7	Dioleoylphosphoethanolamine (DOPE), oleic acid and DSPE-PEG-2000	PLGA	_	DTX	MCF-7 and MDA-MB-231	Balb/C female mice	[183]
8	lecithin and DSPE-PEG	PLGA	_	CPT	MT2 mouse breast cancer cells	_	[61]
9	Tristearin, stearic acid	Pluronic-F68	_	DOX and Elacridar	MDA-MB-435/LCC6/MDR1	_	[184]
10	Dioleoylphosphatidic acid	PLGA-PEG	_	microRNA-222 and PTX	MDA-MB-231	_	[185]
11	Soya lecithin and DSPE-PEG	Pluronic-F68	_	Mycophenolate and Quercetin	MCF-7	Sprague Dawley rats	[145]
12	DSPE-PEG-3000, stearyl amine,	PLA	L-fructose	MTX and beta-carotene	MCF-7	female Wistar rats	[186]
13	Phospholipid S100 and DSPE-PEG-2000	PCL	Fucose	MTX and aceclofenac	MCF-7 and MDA-MB-231	Female BALB/c mice	[187]
14	Egg lecithin, DSPE-PEG-2000	PLGA	cRGD	HCPT	MDA-MB-435 s	_	[188]
15	Soya lecithin and DSPE-PEG-2000	PLGA	iRGD	Isoliquiritigenin	MCF-7, MDA-MB231, and 4T1 cells	female nude mice	[189]
16	DSPE-PEG-2000 and DSPE-PEG-2000-FA	PLGA	Folic acid	Indocyanine green and Cisplatin	MCF-7	_	[190]
17	N,N-bis(2-hydroxyethyl)-N-methyl-N-(2-cholesteryloxycarbonyl aminoethyl	PLA	_	Polo-like kinase 1 siRNA	BT747	BALB/c-nu nude mice	[191]
18	DSPE-PEG-2000	poly (β-amino ester), PBAE	Folic acid	Docetaxel	4T1	BALB/c	[192]

ISSN: 1476-4598