Fig. 8

Representation of development of MTX loaded hybrid nanoparticles conjugated with lactoferrin as targeted delivery agent against cancer, (A) Illustration of development of targeted hybrid nanoconstructs using single step precipitation method along with its internalization following receptor mediated endocytosis, (B) Scanning electron microscopic images of lactoferrin un-conjugated (up) and conjugated (down) hybrid nanostructure, Cell viability study on MCF-7 cells treated with various preparations after (C) 24 h and (D) 48 h, (E) Representation of fluorescence microscopic study for ascertaining the uptake of lactoferrin conjugated and unconjugated nanoparticles. Reproduced with permission from Kumar et al. [214]. Copyright (2022) Elsevier