Fig. 5

Illustration of dual drug loaded (Afatinib and geftinib) in core-shelled construct of lipid-polymeric nanoparticles in nasopharyngeal cancer therapy (A), Transmission electron microscopic images of apatinib, geftinib and dual drug loaded hydrid nanosconstructs (from left to right) (B), In vitro drug release study of apatinib and geftinib from nanostructures loaded with both drugs (C), Fluorescent uptake and cell apoptosis study with different preparations suggesting dual drug loaded system is highly essential in treatment of nasopharyngeal cancer (D), Cellular uptake efficacy of the different formulations of GEF-APT@LPHNs examined by flow cytometer analysis (E). Reproduced with permission from Yu et al. [165]. Copyright (2021) Elsevier