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Fig. 3 | Molecular Cancer

Fig. 3

From: circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer

Fig. 3

circEIF3I promotes pancreatic cancer cells migration and invasion in vitro, and metastasis in vivo. A Two circEIF3I siRNA were designed and qRT-PCR for circEIF3I expression after silencing of circEIF3I in PANC-1 and BxPC-3 cells. B The dot plots showing the enrichment analysis for representative pathway in circEIF3I target genes. C-E Wound healing assay (C), migration (D) and invasion assay (E) verified the effect of circEIF3I knockdown (KD) on PDAC cell migration and invasion ability via si-circEIF3I (Scale bar = 100 μm). F and G Representative photographs of the liver metastasis model established using cells with knocking down (F) and overexpressing (G) of circEIF3I, and HE staining of liver metastatic nodules with original magnification (Scale bar = 200 μm). The number of macroscopic metastases were calculated (right panel). Data are shown as the mean ± SD of three replicates; **P < 0.01; ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598