Skip to main content
Fig. 1 | Molecular Cancer

Fig. 1

From: circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer

Fig. 1

circEIF3I is highly expressed in PDAC and correlated with poor prognosis. A and B The heatmap (A) and volcano plot (B) showing circRNAs expression in 6 PDAC vs. 6 paired adjacent normal tissues (|log2(fold change)|> 2, p < 0.05). C circEIF3I expression in 30 pairs of PDAC tissues and adjacent normal tissues. D circEIF3I expression in 80 PDAC tissues and 30 adjacent normal tissues. E Association analyses of circEIF3I expression and TNM stage. F circEIF3I expression in pathologic T1, T2 and T3 stage of PDAC, with or without lymph node (LN) metastasis. G Representative images of the ISH staining analyses of different stage PDAC tissues using circEIF3I specific probe (Scale bar = 50 μm). H Kaplan–Meier analysis of postoperative overall survival (OS) for 80 PDAC patients with different circEIF3I expression. The low and high levels of circEIF3I expression are separated according to the median value. **P < 0.01; *P < 0.05; ns, not significant

Back to article page

Molecular Cancer

ISSN: 1476-4598