m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism

Table 1 The function of m6A methylation enzymes in RNA metabolism

Type	Regulator	Function	Ref
Writers	METTL3	Catalyzes m6A methylation	[26]
	METTL14	Recognizes target RNAs and stabilizes METTL3	[29]
	WTAP	Regulatory subunit of m6A methyltransferase	[31]
	RBM15	Recruits METTL3 and WTAP to specific RNA sites	[33]
	VIRMA	Locates the m6A methyltransferase complex near the 3’UTR and stop codon regions of RNAs	[34]
	Hakai	Maintains the stability of m6A methyltransferase complex	[35]
	ZC3H13	Anchors WTAP in the nucleus to enhance m6A modification	[36]
	METTL16	Catalyzes m6A methylation	[38]
	METTL5	Induce the m6A methylation of 18 S rRNA	[42]
	ZCCHC4	Induce the m6A methylation of 28 S rRNA	[43]
Erasers	FTO	Removes m6A from RNAs	[45]
	ALKBH3	Removes m6A from RNAs	[46]
	ALKBH5	Removes m6A from RNAs	[46]
Readers	YTHDF1	Promotes mRNA translation initiation	[49]
	YTHDF2	Promotes mRNA degradation	[49]
	YTHDF3	Interacts with YTHDF1 to promote mRNA translation or interacts with YTHDF2 to promote mRNA degradation	[49]
	YTHDC1	Promotes mRNA splicing and regulates RNA nuclear export	[53]
	YTHDC2	Improves the translation efficiency of target mRNA	[54]
	HNRNPA2B1	Promotes primary miRNA processing	[55]
	HNRNPC/G	Interacts with m6A-modifed mRNA	[56, 57]
	HNPNPR	Associates with m6A modification	[58]
	IGF2BP1-3	Promotes the stability and translation of mRNA	[59]
	NKAP	Promotes the splicing and maturation of mRNA	[60]
	eIF3	Promotes mRNA translation	[61]

ISSN: 1476-4598