Table 1 Patients demographics (n = 15)

Median age at diagnosis (range)

56 (16–72)

Median age at enrollment (range)

57 (16–72)

Gender

 - Male

 - Female

7 (47%)

8 (53%)

ECOG at baseline:

 - 0

 - 1

10 (67%)

5 (33%)

Median tumor size (range) at diagnosis (mm)

60 (13–250)

Tumor extension at diagnosis:

 - Localized

 - Locally advanced

 - Metastatic

6 (40%)

2 (13%)

7 (47%)

Tumor extension at enrollment:

 - Locally advanced

 - Metastatic

2 (13%)

13 (87%)

IHC-SDH:

 - Positive

 - Negative

 - Not available

5 (33%)

8 (53%)

2 (13%)

Any mutation:

 - Yes

 - No

 - Not available

10 (67%)

4 (27%)

1 (6%)

SHD mutation:

 - SDH

 - Other gene

 - No mutation

 - Not available

6 (40%)

4 (27%)

4 (27%)

1 (6%)

Any alteration in any gene:

 - Yes

 - No

12 (80%)

3 (20%)

Any alteration in SDH:

 - Yes

 - No

9 (60%)

6 (40%)