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Table 1 Baseline characteristics of the participants

From: Anlotinib plus icotinib as a potential treatment option for EGFR-mutated advanced non-squamous non-small cell lung cancer with concurrent mutations: final analysis of the prospective phase 2, multicenter ALTER-L004 study

Characteristic

ITT (n = 60)

ESA (n = 57)

Median Age (range), years

62 (35–72)

62 (35–72)

≥60 years

35 (58.3%)

35(59.6%)

Sex (male)

26 (43.3%)

25(43.9%)

Clinical stage

  

IIIB

1 (1.7%)

1(1.8%)

IIIC

1 (1.7%)

1(1.8%)

IV

58 (96.7%)

55(96.5%)

Smoking history

  

Ever

11 (18.3%)

11(19.3%)

Current

9 (15.0%)

7(12.3%)

Never

40 (66.7%)

39(68.4%)

ECOG PS

  

0

22 (36.7%)

22(38.6%)

1

37 (61.7%)

34(59.6%)

2

1 (1.7%)

1(1.8%)

Recurrent NSCLC

2 (3.3%)

2(3.5%)

Brain metastases

21 (35.0%)

21(36.8%)

EGFR mutations

  

19del

30 (50.0%)

30(52.6%)

L858R

30 (50.0%)

27(47.4%)

Concurrent mutations

31 (51.7%)

30(52.6%)

Pathogenic concurrent mutations

29 (48.3%)

28(49.1%)

  1. Data are presented as median (range) or n (%).
  2. ITT, intention-to-treat; EAS, efficacy analysis set; ECOG PS, Eastern Cooperative Oncology Group performance status; NSCLC, non-small-cell lung cancer; EGFR, epidermal growth factor receptor gene.