Fig. 3
Inflammation primes immune cell infiltration during E-to S transition
(A) Graphical representation the distribution of genes upregulated in S-AOIs as compared to E- AOIs in our analysis. Pie Chart displays the percentage of immune-related genes in this list on the total. Histogram represents the percentage distribution of immune related genes in the four main immune related processes. Some of the genes were included in more than one category, according to their multiple functions. (B) Chord plot represents the connections between immune related genes upregulated in S-AOIs and the four main immune related processes. (C) Histograms representing the relative expression of selected markers of immune populations. Data are expressed as fold change between the average expression in the S-AOIs as compared to the average expression in the E-AOIs. (D) Deconvolution results, obtained from gene expression data, showing scaled abundance percentage of each immune cell population in E- and S-AOIs. (E) Deconvolution results, obtained from gene expression data, showing scaled abundance percentage of fibroblasts and endothelial cells in E- and S-AOIs. (F) Radar plot showing the average expression level of principal pro-inflammatory and EMT genes in S- and E-AOIs. (G) Box plots representing the expression levels of LGALS9, HAVRCR2 and CD86 in the four types of AOIs during E to S transition. In this figure p-values are represented as follow: *<0.05, **<0.01 ***<0.001