Skip to main content
Fig. 4 | Molecular Cancer

Fig. 4

From: Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7

Fig. 4

m6A modified circ-FBXW7 expression in resistant lung cancer cells A The m6A levels of total RNAs from resistant cells were more abundant than that of sensitive original cells. B The differentially expressed hsa-circ-0001451 (circ-FBXW7) was matched in circRNA Database and the structure was illustrated for mechanistic understanding. C circ-FBXW7 was lowly expressed in Osimertinib resistant cells and in stem-like cells. D-F The lentiviral based YTHDF3 knock-down systems inhibited its expression significantly, and LC–MS/MS tests revealed the YTHDF3 associated m6A levels. F-G YTHDF3 inhibition decreased the m6A modification and therefore promoted the stem cells renewal that identified by spheres forming assay and surface marker of ALDH1A1

Back to article page

Molecular Cancer

ISSN: 1476-4598