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Fig. 2 | Molecular Cancer

Fig. 2

From: Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1

Fig. 2

Identification and validation of key miRNA and downstream mRNA. A The heatmap and B volcano plot showing the profile of differentially expressed genes based on dataset GSE28425 in the context of OS. C The Kaplan–Meier plot related miR-144-3p expression based on dataset GSE39052. The RT-qPCR results of key miRNA based on D five OS cell lines and one osteoblastic cell line, as well as E human OS tissue and paracancerous tissue samples. F The binding site sequence of miR-144-3p and ZEB1. G The dual luciferase assay indicated that miR-144-3p can bind to ZEB1. The RT-qPCR results of key mRNA based on H five OS cell lines and one osteoblastic cell line, as well as I human OS tissue and paracancerous tissue samples. J IHC micrographs based on 60 tissue sections. K The Kaplan–Meier plot for ZEB1 based on the clinical data of 60 patients corresponding to tissue sections

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Molecular Cancer

ISSN: 1476-4598