Fig. 1
From: Protein regulator of cytokinesis 1: a potential oncogenic driver
Clinical significance, functional roles and upstream regulators of PRC1. (A) The Expression profiles of PRC1 mRNA in cancers by the analysis of RNA-seq data from TCGA + GTEx database. (B) Differential expression of PRC1 protein in certain cancers according to the CPTAC database. (C) Analysis of overall survival (OS) based on PRC1 expression, with patients falling into PRC1high (> median) and PRC1low (< median) groups in each cancer type. GSEA-based analysis of cell cycle-related pathways (D), DNA damage (E) and DNA repair (F) were performed through analyzing PRC1-associated differential gene expression data in 36 cancer types. (G) Favorable prognostic value of PRC1 methylation in cancers determined using the MethSurv database. (H) Potential transcription factors responsible for regulating PRC1 expression. (I) Potential miRNAs targeting PRC1. Significance is indicated as follows: ns, p ≥ 0.05, *p < 0.05, **p < 0.01, and ***p < 0.001