Fig. 5

High sensitivity of CGS3 subtype to radiation therapy. A Expression patterns of GPICS120 genes in gastric tumor tissues from ARTIST cohort (n = 331). Tumors were stratified according to GPICS120. Subtype-specific gene expression patterns were well conserved in the tumors from the ARTIST cohort. B Forest plots showing hazard ratio (HR) for recurrence for adjuvant XPRT treatment over XP treatment in consensus subtypes of GAC tumors from patients in the ARTIST clinical trial. A Cox proportional hazard regression model was used to analyze the interaction between DFS of patients with CGS3 tumors and the rest of patients (non-CGS3 tumors and XPRT treatment. The dotted line represents the 95% confidence interval (CI) of HRs. XP, capecitabine + cisplatin; XPRT, XP + radiotherapy