Fig. 4

Association of consensus subtypes with treatment benefit. A, B Box plots of CD8 T-cell immunity scores (CD8TRS) (a) and anti-PD-L1 response scores (b) in consensus subtypes. The boundaries of each box indicate the 25th to 75th percentile, and the black line within the box marks the mean. Whiskers above and below the box indicate the 10th and 90th percentiles. *P < 0.001 by Student t-test. C Scatter plots of CD8 T-cell immunity scores and anti-PD-L1 response scores in training and validation cohorts. Colors indicate consensus subtypes as indicated. Black lines indicate loess regression