Fig. 1

Consensus subtypes of gastric adenocarcinoma discovered by cluster-of-cluster assignment. A Hierarchical dendrogram of supercluster subtypes identified by cluster-of-cluster assignment (COCA). GAC tumors were grouped according to shared features of independently discovered molecular subtypes. Tumors from 6 GAC cohorts (Korea, Samsung, TCGA, Shanghai, Shanxi, and Singapore1, n = 1427) were stratified by 8 genomic classification methods, and subtype information was used for clustering with ConsensusClusterPlus (v.3.12). Columns and rows represent GAC tumors in the discovery/training set. B Delta area plot. The plot shows the relative change in area under the cumulative distribution function (CDF) curve comparing k and k − 1. C Tracking plot. The plot shows the cluster assignment of tumors (columns) for each k (rows) by color. This plot provides a view of item cluster membership across different values of k. D Clinical significance of 6 consensus subtypes of GAC in discovery/training cohorts (n = 1185). Patients in the Korea, TCGA, Shanxi, and Samsung cohorts were included in the analysis; clinical data from the Shanghai and Singapore1 cohorts were not available. OS, overall survival. P-value indicates the significance from log-rank test