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Fig. 7 | Molecular Cancer

Fig. 7

From: m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma

Fig. 7

Development of the IGF2BP2-based prognostic scoring system for LUAD. A The global regulatory network of IGF2BP2-FLT4-PI3K-Akt signaling-angiogenesis. B Bubble plots demonstrating the correlation between the IGF2BP2-FLT4-PI3K-Akt signaling-angiogenesis key genes and clinical indicators in the TCGA-LUAD dataset. C, D Survival curves of OS and RFS outcomes for the low and high-score patients stratified by the IGF2BP2-based model in the TCGA-LUAD dataset. E Time-independent ROC curves for evaluating the performance of the IGF2BP2-based model in predicting OS and RFS outcomes in the TCGA-LUAD dataset. F, G External validation of OS analysis and time-independent ROC curves in the GSE72094 dataset. H, I Uni- and multivariate cox regression results on the IGF2BP2-based model and clinical parameters with patient survival in the TCGA-LUAD dataset. J Construction of the nomogram composed of the IGF2BP2-based model and stage. K-M Calibration curves for the nomogram-predicted and actual one-, three- and five-year OS outcomes

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Molecular Cancer

ISSN: 1476-4598