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Fig. 5 | Molecular Cancer

Fig. 5

From: m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma

Fig. 5

Overexpression of IGF2BP2 in endothelial cells activates the PI3K-Akt signaling to promote angiogenesis. A Circle diagram showing the relationships between LUAD_IGF2BP2 ligand genes and En_IGF2BP2 receptor genes. The gene colors characterize their logFC and the pathway colors are aligned with the circles. The first loop genes are shared markers for the LUAD_IGF2BP2 and the En_IGF2BP2 subpopulations, the second loop is a non-shared marker, and the third and fourth loops are signaling pathways. B Violin diagram showing the expression pattern of exosomal markers in the LUAD subpopulations. C Pathway map showing the PI3K-Akt signaling pathway activated in the En_IGF2BP2 subpopulation

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Molecular Cancer

ISSN: 1476-4598