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Fig. 3 | Molecular Cancer

Fig. 3

From: m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma

Fig. 3

Endothelial cell landscape in metastatic LUAD. A The single-cell atlas showing endothelial cell subpopulations. B Dotted line graph showing changes in abundance of endothelial cell subpopulations in control, primary and metastatic LUAD. C The single-cell atlas mapping the expression of IGF2BP2 in endothelial cells. D Immunofluorescence assay-fluorescent probe assay showing IGF2BP2 expression in endothelial cell subpopulations with high and low CD34 expression. Bar, 50 μm. E Shared markers of specific cell subpopulations (LUAD_IGF2BP2 and En_IGF2BP2). F Cluster-bubble plots demonstrating biological functions shared by specific cell subpopulations. G Cluster-bubble plots demonstrating KEGG pathways shared by specific cell subpopulations. H GSEA plots demonstrating the significant activation of biological signals related to secretion, secretion and synthesis of vesicles and phagocytosis of contents diffusion in specific cell subpopulations En_IGF2BP2 (left) and LUAD_IGF2BP2 (right)

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Molecular Cancer

ISSN: 1476-4598