Fig. 6

Antitumor effect of nanoinhibitor in vivo. A Schematic illustration of the experimental protocol in CT26-Luc tumor-bearing Balb/c mice. B Schematic illustration of the hyperthermic intraperitoneal perfusion procedure. C Bioluminescence images of tumor-bearing mice individually treated with PBS, Nano 37 °C (50 mg/L), PBS 43 °C, Nano 43 °C (50 mg/L) at day 0, 5, 10, 20, 30, 40, and 50. D Representative images of tumor tissues harvested from intraperitoneal at day 17. E Tumor immunohistochemical staining of HSP90 and cleaved GSDMD in different treatment groups. GSD-N, GSDMD-N fragment. F Bioluminescence intensity of tumors in different groups of mice individually corresponding to (C). G Survival curves of mice receiving the indicated treatment. i.p., intraperitoneal injection. Indi, individual