Fig. 3
From: Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring
Enrichment and typical detection methods for CTCs. Working with CTCs includes the following three analytical steps: enrichment, detection, and analysis. Enrichment includes label-dependent approaches based on antibodies used for positive or negative enrichment of CTCs, as well as label-independent technologies. In the last decade, individual CTCs or CTC clusters have been analyzed downstream at the DNA, RNA, or protein level