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Fig. 2 | Molecular Cancer

Fig. 2

From: Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma

Fig. 2

PD-L1+ EVs derived from different cell types released clustered by response to therapy and evaluation of PFS and OS in patients with PD-L1+ EVs derived from melanoma cells and CD8+ cells. A Scatter plot with median of the percentage of PD-L1+ EVs from responders (n = 38) and non-responders (n = 33) (Mann Whitney t test**p < 0.01, *** p < 0.001). B Kaplan–Meier survival curve analysis according to PD-L1+ EVs quartiles, with PD-L1+ EVs from melanoma and CD8 T cells as respect to PFS, and C the distribution of the best responses stratifying patients by quartiles of PD-L1+ EVs from melanoma cells. D Kaplan–Meier survival curve analysis according to PD-L1+ EVs quartiles, with PD-L1+ EVs from melanoma cells as respect to OS

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Molecular Cancer

ISSN: 1476-4598