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Fig. 1 | Molecular Cancer

Fig. 1

From: CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein

Fig. 1

circRTN4 is upregulated in PDAC cells and primary tumors and associates with liver metastasis. A CircRTN4 was upregulated in a panel of PDAC cells, compared to non-tumor HPDE cells. B CircRTN4 was significantly upregulated in PDAC primary tumors, compared to respective adjacent non-tumor tissues (n = 88). CircRTN4 was upregulated in 60% of the PDAC primary tumors (53 out of 88), while 18% of PDAC patients showed downregulated circRTN4 (16 out of 88), and 22% of PDAC patients showed unchanged circRTN4 (19 out of 88). C CircRTN4 was upregulated in PDAC primary tumors from patients with liver metastasis. D CircRTN4 was formed by back-splicing of exon 4 and 5 of RTN4 mRNA. Data represent mean ± SD from at least three independent experiments (*p < 0.05; **p < 0.01***p < 0.001)

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Molecular Cancer

ISSN: 1476-4598