Fig. 2
From: The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors
The m6A methylation modification process of mRNA: METTL3, WTAP, METTL14 and other methyltransferases act as “writers”, making the m6A site of mRNA methylated. FTO and ALKBH5 acted as demethylase, and their effects were opposite to those of methyltransferase. In addition, there is a class of m6A recognition and binding proteins, mainly including YTHDFs and YTHDCs, which can bind to this methylation site to induce mRNA decay, thus affecting protein synthesis and the occurrence and development of related tumors