Table 2 Overview of circRNAs in drug-resistant tumors

LUAD

circPVT1

CDDP/MTA

miR-145-5p/ABCC1 axis

Upregulated

Prognostic

[120]

CDR1-AS

PTX/CDDP

EGFR/PI3K signalling pathway

Upregulated

Prognostic

[105]

SCLC

circESRP1

CDDP/ADM/DT-PACE

miR-93-5p/Smad7/p21(CDKN1A)

Downregulated

Prognostic and Therapeutic targets

[121]

NSCLC

circ_0002483

PTX

miR-182-5p/Grb2、Foxo1、Foxo3

Downregulated

Therapeutic targets

[122]

circ_0076305

CDDP

miR-296-5p/STAT3

Upregulated

Therapeutic targets

[123]

circRNA_103762

CDDP

CHOP

Upregulated

Therapeutic targets

[124]

hsa_circ_0001946

CDDP

NER signalling pathway

Downregulated

Diagnosis and Prognostic

[125]

hsa_circ_0004015

Gefitinib

miR1183-PDK1 axis

Upregulated

Therapeutic targets

[25]

Breast cancer

hsa_circ_0006528

ADM

miR-7-5p/Raf_1 axis

Upregulated

Unknown

[113]

circKDM4C

ADM

miR-548p/PBLD axis

Downregulated

Prognostic

[128]

circMTO1

Monastrol

TRAF4/Eg5 pathway

Downregulated

Prognostic and Therapeutic targets

[129]

circAMOTL1

PTX

AKT signalling pathway

Upregulated

Therapeutic targets

[130]

circ-ABCB10

PTX

Let-7a-5p /DUSP7 axis

Upregulated

Therapeutic targets

[131]

Prostate cancer

circFoxo3

DTX

Foxo3

Downregulated

Prognostic and Therapeutic targets

[132]

hsa_circ_0004870

ENZ

RBM39

Downregulated

Diagnosis and Prognostic

[134]

circRNA17

ENZ

miR-181c-5p/ARv7 signalling pathway

Downregulated

Therapeutic targets

[135]

Gastric cancer

circPVT1

PTX

miR-124-3p/ZEB1

Upregulated

Therapeutic targets

[139]

circFN1

CDDP

miR-182-5p

Upregulated

Therapeutic targets

[106]

circAKT3

CDDP

PI3K/AKT signalling pathway

Upregulated

Therapeutic targets

[140]

circCCDC66

CDDP

miR-618 and releasing BCL2

Upregulated

Therapeutic targets

[136]

circMTHFD2

MTA

miR-124/MDR-1

Upregulated

Drug targets

[141]

circ0001546

OXA

ATM/Chk2/p53

Downregulated

Diagnosis and Prognostic

[115]

circRACGAP1

Apatinib

miR-3657/ATG7 axis

Upregulated

Therapeutic targets

[142]

Colorectal cancer

circ_0000338

5-FU/OXA

unknown

Upregulated

Drug targets

[143]

CIRS-122

Apatinib

miR-122-PKM2

Upregulated

Therapeutic targets

[144]

hsa_circ_0007031

5-FU

miR-885-3p/AKT3

Upregulated

Drug targets

[107]

hsa_circ_0000504

5-FU

miR-485-5p/STAT3/AKT3

Upregulated

Drug targets

[107]

hsa_circ_0048234

5-FU

miR-671-5p/EGFR axis

Downregulated

Drug targets

[107]

hsa_circ_0079662

OXA

hsa-miR-324-5p/ HOXA9/ TNF-α

Upregulated

Unknown

[145]

Osteosarcoma

circPVT1

ADM/CDDP

unknown

Upregulated

Diagnosis and Prognostic

[24]

circ-LARP4

ADM/CDDP

miR-424

Downregulated

Unknown

[116]

hsa_circ_001569

CDDP

Wnt/β-catenin signalling pathway

Upregulated

Therapeutic targets

[149]

ESCC

circRNA_100367

Radiation resistance

miR217/WNT3

Upregulated

Therapeutic targets

[151]

circITCH

Radiation resistance

Wnt/β signalling pathway

Downregulated

Therapeutic targets

[152]

circRNA_001275

CDDP

miR-370-3p/ Wnt7a

Upregulated

Diagnosis and Therapeutic targets

[153]

Nasopharynx cancer

circCRIM1

DTX

miR-422a/FOXQ1

Upregulated

Prognostic and Therapeutic targets

[154]

Bladder cancer

hsa_circ_0000285

CDDP

miR-124 and miR-558

Downregulated

Prognostic

[156]

circRNA Cdr1as

CDDP

miR-1270/APAF1

Upregulated

Therapeutic targets

[157]

Ovarian cancer

circRNA Cdr1as

CDDP

miR-1270/SCAI

Downregulated

Unknown

[158]

circCELSR1

PTX

miR-1252/FOXR2

Upregulated

Therapeutic targets

[159]

AML

circPAN3

ADM

circPAN3-miR-153-5p/miR-183-5p-XIAP axis or AMPK/mTOR pathway

Upregulated

Drug targets

[161, 162]

circMYBL2

quizartinib

FLT3-ITD signalling pathway

Upregulated

Therapeutic targets

[82]

f-circPR

Ara-C

p-AKT signalling

Upregulated

Diagnosis and Therapeutic targets

[36]

f-circM9

Ara-C

MAPK and AKT1-induced signalling

Upregulated

Diagnosis and Therapeutic targets

[36]

CML

circ_0009910

imatinib

miR-34a-5p/ ULK1-induced autophagy

Upregulated

Drug targets

[165]

circBA9.3

TKIs

BCR-ABL pathway

Upregulated

Therapeutic targets

[166]

circ_100053

imatinib

BCR-ABL pathway

Upregulated

Diagnosis and Therapeutic targets

[168]

MM

hsa_circ_0007841

BTZ

unknown

Upregulated

Diagnosis and Prognostic

[170]

Pancreatic cancer

circHIPK3

GEM

miR-330-5p/RASSF1

Upregulated

Prognostic and Drug targets

[171]

Cholangiocarcinoma

circ-SMARCA5

CDDP/GEM

unknown

Downregulated

Prognostic

[172]

HCC

circ_0003418

CDDP

Wnt/β-catenin signaling pathway

Downregulated

Unknown

[173]

Renal carcinoma

hsa_circ_0035483

GEM

miR-335/CCNB1

Upregulated

Unknown

[174]

Glioblastoma

circNFIX

TMZ

miR-132

Upregulated

Prognostic and Therapeutic targets

[175]