From: Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications
NcRNAs | Parent cell | Target cell | Biological function | Reference |
---|---|---|---|---|
miR-221 | U87MG | SHG-44 | Promote proliferation, migration and TMZ resistance | [62] |
lncRNA-ATB | Glioma cells | Normal human astrocytes | Promote invasion | [6] |
miR-148a | Glioma cells | Glioma cells | Promote proliferation and metastasis | [63] |
miR-451/miR-21 | Glioma cells | Microglia/macrophages | Promote proliferation and immune suppression | [24] |
miR-1587 | Mesenchymal Stem Cells | Glioma Stem-like Cells | Increase tumorigenicity | [64] |
miR-1 | Glioblastoma cells | Endothelial cells and glioblastoma cells | Inhibit angiogenesis, invasion, and neurosphere formation | [65] |
miR-124 | Mesenchymal stem cells | glioblastoma cells | Inhibit proliferation, migration and confer chemosensitivity | [28] |
miR-302-367 | Glioma stem-like cells | Glioblastoma cells | Inhibit growth | [66] |
miR-7 | Mesenchymal stem cells | Glioblastoma cells | Increase apoptosis and suppress growth | [30] |
miR-584 | Mesenchymal stem cells | Glioma cells | Suppress tumor progress | [29] |
miR-146b | Marrow stromal cells | Gliosarcoma cells | Reduce glioma growth in vivo | [25] |
miR-124a | Mesenchymal stem cells | Glioma stem cell | Antiglioma agent | [31] |
miRNA-199a | Mesenchymal stem cells | Glioma cells | Inhibit proliferation, invasion and enhance chemosensitivity | [27] |
miR-375 | Marrow stromal cells | Glioma cells | Inhibit glioma progression | [26] |
lncRNA-HOTAIR | Glioblastoma cells | Endothelial cells | Promote angiogenesis | [49] |
lincRNA-CCAT2 | Glioma cells | Endothelial cells | Promote angiogenesis | [67] |
lincRNA-POU3F3 | Glioma cells | Endothelial cells | Promote angiogenesis | [68] |
miR- 26a | Glioma stem cells | Endothelial cells | Promote angiogenesis | [69] |
miR-21 | Glioma stem cells | Endothelial cells | Promotes angiogenesis | [70] |
miR-9 | Glioma cells | Endothelial cells | Promote tumorigenesis and angiogenesis | [71] |
miR-10a, miR-21 | Hypoxic glioma cells | Myeloid-derived suppressor cells | Mediate immunosuppressive microenvironments | [72] |
miR-29a, miR-92a | Hypoxic glioma cells | Myeloid-derived suppressor cells | Mediate immunosuppressive microenvironments | [73] |
miR-1246 | Hypoxic glioma cells | Macrophages | Mediate immunosuppressive microenvironment | [74] |
miR-21 | Glioma cells | Microglia | Mediate immunosuppressive microenvironment | [75] |
miR-151a | TMZ-resistant glioblastoma cells | TMZ-sensitive glioblastoma cells | Enhances chemosensitivity to TMZ | [76] |
lncRNA-SBF2-AS1 | TMZ-resistant glioblastoma cells | Chemoresponsive glioblastoma cells | Enhances chemoresistance to TMZ | [77] |
circATP8B4 | Radioresistant glioma cells | Normal glioma cells | Promote cell radioresistance | [78] |
miR-301a | Hypoxic glioma cells | Normoxia-cultured glioma cells | Promote radiation resistance | [79] |
lncRNA-AHIF | Radioresistant glioblastoma cells | Glioblastoma cells | Promote invasion and radioresistance | [48] |