From: Targeting PI3K in cancer: mechanisms and advances in clinical trials
LncRNAs | Up- or down-regulation | Cancer type | Affected biological process (Involved factors) | References |
---|---|---|---|---|
CRNDE | Up | Gallbladder carcinoma; Non-small cell lung carcinoma; Colorectal cancer; Gastric cancer; Cervical cancer; Heptaocellular cancer | Cell roliferation, growth, migration, invasion and apoptosis; glucose and lipid metabolism (Gene expression in PI3K pathway: MMP-9, JUK-1, ERK and AKT) | |
OIP5-AS1 | Up | Multiple myeloma; Osteosarcoma | Cell proliferation, cycle and apoptosis; cisplatin resistance, (miRNA-410, miRNA-340-5p and expression of lysophosphatidic acid acyltransferase) | |
CCAT1 | Up | Thyroid carcinoma; Squamous cell carcinomas | Cell proliferation, migration, and invasion (miRNA-143; EGFR expression) | |
H19 | Up | Retinoblastoma, Melanoma | Cell viability, migration, invasion, and apoptosis (miRNA-143, RUNX2, Phosphorylation of key kinases) | |
HOTAIR | UP | Gastric cancer; Adenocarcinoma of esophagogastric junction; Leukemia; Melanoma; Gliomas | Cell proliferation, metastasis and apoptosis; cisplatin resistance; acquired multidrug resistance to imatinib (miRNA-143, miRNA-34a, miRNA-152-3p, miRNA-126, miRNA-326, FGF1) | |
NEAT1 | Up | Myeloma; Cervical carcinoma; Gastric cancer | Cell proliferation, viability, migration, invasion, apoptosis, and cell cycle. (microRNA-17) | |
HULC | Up | Bladder cancer; Leukemia; Gliomas; Osteosarcoma; Liver cancer; Gastric cancer | Cell viability, growth, migration, invasion and autophagy (PTEN, miRNA15a, autophagy-P62, miRNA-122) | |
AB073614 | Up | Colorectal cancer | Cell cycle, proliferation, migration, and invasion | [233] |
PTTG3P | Up | Hepatocellular carcinoma | Cell proliferation, migration, invasion, tumorigenesis and metastasis | [234] |
MALAT1 | Up | Cervical cancer; Epithelial ovarian cancer; Breast cancer; Osteosarcoma; Cholangiocarcinoma; Non-small cell lung carcinoma; Hepatocellular carcinoma; Renal cell carcinoma | Cell proliferation, invasion, metastasis, viability and mobility; stemness-related factor activation; epithelial-to-mesenchymal transition; cisplatin resistance (PI3Kp85α, miRNA-22-3p, miRNA195, miRNA-124, MiRNA-101-3p, miRNA-129-5p) | |
ATB | Up | Bladder cancer; Prostate carcinoma | Cell proliferation, migration and invasion; mitogenic; epithelial-mesenchymal transition (microRNA-126, KRAS,) | |
BC087858 | Up | Non-small-cell lung cancer | Cells invasion; resistance to EGFR-TKIs (ZEB1, Snail.) | [248] |
Linc00659 | Up | Colorectal cancer | Cell growth inhibition and apoptosis | [249] |
Linc00152 | Up | Lung cancer; Gallbladder cancer | Cell proliferation, invasion, migration, apoptosis, and G1 phase rates | |
Linc00462 | Up | Hepatocellular carcinoma | Cell proliferation, invasion and migration | [252] |
Linc01296 | Up | Prostate cancer; Colorectal cancer | Tumorigensis, cell proliferation, migration, invasion, and liver metastasis; epithelial-mesenchymal transition; chemoresistance to 5-fluorouracil (miRNA-26a, mucin1, GALNT3) | |
Linc003121 | Down | Thyroid cancer | Cell proliferation, Invasion, and tumorigenicity | [255] |
UCA1 | Up | Gastric cancer; Bladder cancer | Cell proliferation, migration, invasion, apoptosis and cell cycle | |
ecCEBPA | Up | Gastric cancer; Hepatic cancer | Disease progression | |
Ftx | Up | Hepatocellular carcinoma | Cell growth (miRNA-545, RIG-I) | [261] |
RMEL3 | Up | Melanoma | Cell survival and proliferation (PTEN) | [262] |
LncARSR | Up | Hepatocellular Carcinoma | Doxorubicin resistance (PTEN) | [206] |
BDLNR | Up | Cervical cancer | Cell proliferation, migration, and death; anti-cancer effects of baicalein (YBX1, PIK3CA promoter) | [263] |
ANRIL | Up | Cervical cancer; Osteosarcoma; Gliomas | Cell proliferation, migration, invasion, and apoptosis (miRNA-34a, Sirt1) | |
ROR | Up | Non-small-cell lung cancer | Cell proliferation, migration, and invasion; cisplatin resistance | [267] |
PlncRNA-1 | Up | Colorectal cancer | Cell proliferation, migration, invasion, and apoptosis | [268] |
MYD88 | Up | Hepatocellular carcinoma; | Cell proliferation and metastasis (H3K27Ac) | [269] |
RP4 | Down | Colorectal cancer | Cell proliferation, growth, and early apoptosis (SH3GLB1, miRNA-7-5p) | [270] |
OIP5-AS1 | Down | Osteosarcoma, myeloma | Cell growth; cisplatin resistance (miRNA-340-5p, LPAATbeta, miRNA-410, KLF10) | |
MEG3 | Down | Endometrial carcinoma; Breast cancer; Cervical cancer; Pancreatic cancer; Lymphoma; Gliomas | Cell proliferation, migration, invasion, metastasis, and apoptosis; autophagy; glycolysis; epithelial-mesenchymal transition; chemoresistance (Combine directly with PI3K, miRNA-21, cytomembrane translocation of AKT) | |
GAS5 | Down | Colorectal cancer; Esophageal squamous cell carcinoma; Breast cancer; Malignant pleural mesothelioma; Osteosarcoma; Prostate cancer | Cell proliferation and migration, viability, migration and invasion; apoptotic responses to conventional chemotherapies (miRNA-203a, TIMP2, miRNA-196a-5p, FOXO1) | |
RNA-422 | Up | Colorectal cancer | Cell proliferation, migration, and invasion | [278] |