From: Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
Compound | Mechanism of action | Ref |
---|---|---|
Gold nanoparticle | Inhibits proliferation and migration of pancreatic cancer cells and pancreatic stellate cells by disrupting the bidirectional communication; inhibit matrix deposition, enhance angiogenesis, and inhibit tumor growth | [142] |
GDC-0449 + polymeric prodrug-based nanoparticles | Reduces fibroblast mediated drug resistance; Specifically reduce collagen, α-SMA and glioma-associated protein1 (GLI-1) expression in tumor tissues | [143] |
Methacrylate-based Gemcitabine-monomer conjugate | Sustained release of Gemcitabine and enhances cytotoxicity against tumor growth | [144] |
3,4-Difluorobenzylidene curcumin + styrene-maleic acid copolymer | Efficient intracellular delivery of 3,4-Difluorobenzylidene curcumin that specifically target tumor microenvironment | [145] |
Bisnaphthalimidopropyldi-amino-octane + CH (5)-PAA polymer | Reduces tumor cell proliferation and tumor growth by inducing apoptosis | [146] |
Gemcitabine + Hybrid nanoparticle | Systemic and targeted delivery of Gemcitabine to reduce tumor growth | [147] |
Hybrid iron oxide-gold nanoparticles | Targeted drug delivery for tumor retardation | [148] |
Paclitaxel + nanoemulsion | Enhances chemotherapeutic efficacy of drug by targeted delivery | [149] |