From: Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
Generation
Representative
In vitro
In vivo
PK
Down-regulate ABC transporter
1st
verapamil, cyclosporin A, tamoxifen
+
–
2nd
PSC833, S97882, VX-710
3rd
GF120918, XR9576, R101933, LY335979
4th
neochamaejasmin B, curcumin