Fig. 4From: Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cellsTKIs’ potential mechanism to reverse MDR. TKIs inhibit ABC transporter in manner of: (i) directly inhibiting the function of ABC transporter through blocking the ATP-binding site or changing the single nucleotide polymorphisms (SNPs) (ii) down-regulating the expression of ABC transporter and consequently influencing its normal function. Which increases intracellular drug concentration and results in reversal of MDRBack to article page