Fig. 1

Origins of germinal center (GC)-derived and non-GC derived molecular subtypes of DLBCL. Germinal center (GC)-derived molecular subtypes of B-cell lymphoma originate from GC B cells that are blocked at different stages of development and have distinctive mechanisms of oncogenic activation and different clinical outcomes. T cell/histiocyte-rich large B-cell lymphoma. (T/HRLBCL) is thought to originate from a progenitor cell of germinal center origin. T/HRLBCLs are characterized by scattered large B cells immersed in a T-cell rich background with frequent presence of histiocytes. GC B cell (GCB)-like diffuse large B-cell lymphoma (DLBCL) originate from light zone B cells. Activated B cell-like (ABC) DLBCL shows characteristics of the late post–germinal center plasmablasts, a normally transient state that is committed to terminal plasmacytic differentiation. Primary mediastinal (thymic) large B-cell lymphomas (PMLBCL) shows characteristics of late post-germinal center thymic B cells and are thought to originate from thymic asteroid medulla B cells. Adapted from REF [3, 70, 86]. Information for this figure was gleaned from the following references: references: T/HRLBCL [37, 38, 42, 43, 45–47, 111, 112, 116], GCB-DLBCL [2, 3, 13, 35, 39, 40, 42, 43, 65–74, 86], ABC-DLBCL [2, 3, 13, 35, 39, 40, 42, 43, 65, 66, 70, 86, 87, 96] and PMLBCL [1, 3, 9, 35, 48, 49, 51, 52, 62, 63, 70, 86]. Abbreviations: FDC follicular dendritic cell, Ag antigen