Table 2 Cox analysis of the prognostic variables on the overall survival in patients ( Whole blood)

Univariate analysis

 NEAT1_v1, Low/High

0.004*

0.415 (0.227–0.758)

 NEAT1_v2, Low/High

0.285

1.421 (0.746–2.708)

 NEAT1_v2, High Alone^a

0.006*

0.426 (0.231–0.784)

 Gender, Male/Female

0.399

1.290 (0.714–2.330)

 Age, <56/≥56 years^b

0.967

0.988 (0.544–1.793)

 Tumor (T) stage, T1–2/T3–4

0.124

0.399 (0.124–1.288)

 Nodal (N) status, N0/N1

<0.001*

0.120 (0.056–0.257)

 N0/N2

<0.001*

0.297 (0.143–0.617)

 Distant metastasis (M), M0/M1

<0.001*

0.102 (0.055–0.188)

 Lymphatic/vascular invasion, No/Yes

<0.001*

0.243 (0.135–0.438)

 Perineural invasion, No/Yes

0.001*

0.342 (0.179–0.653)

 Extranodal tumor deposit, No/Yes

0.005*

0.389 (0.201–0.753)

 AJCC Stage^c, I–II/III–IV

<0.001*

0.205 (0.066–0.426)

 Differentiation, G1–G2/G3–G4

0.058

0.543 (0.289–1.022)

 Pathology, Adenocarcinoma/Mucinous or signet-ring carcinoma

0.712

0.859 (0.384–1.923)

 Size, <5/≥5^b

0.598

1.187 (0.627–2.247)

Multivariate analysis

 NEAT1_v1, Low/High

0.068

 NEAT1_v2, High Alone^a

0.038*

0.519 (0.280–0.965)

 Nodal (N) status, N0/N1

<0.001*

0.199 (0.088–0.452)

 N0/N2

0.017*

0.402 (0.189–0.851)

 Distant metastasis (M), M0/M1

<0.001*

0.193 (0.099–0.374)

 Lymphatic/vascular invasion, No/Yes

0.996

 Perineural invasion, No/Yes

0.366

 Extranodal tumor deposit, No/Yes

0.645

 AJCC Stage^c, I–II/III–IV

0.498