Figure 5

H. pylori induced activation of β-catenin involves LRP6 and Dvl. A In non-infected cells, β-catenin is phosphorylated by a destruction complex consisting of Axin, APC, GSK3β and CK1α and subsequently degraded by the 26S proteasome. B, Infection of gastric epithelial cells with H. pylori induces LRP6 phosphorylation and activation of β-catenin in a LRP6- and Dvl-dependent manner, resulting in β-catenin translocation to the nucleus and induction of target gene expression (Axin2). Further, other factors, e.g. c-Met or EGFR contribute to β-catenin signaling in H. pylori-infected epithelial cells.