Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

Table 1 HIF-1α target genes upregulated in response to hypoxia in GL261 control cells

Affymetrix ID	Gene Symbol	Gene Title	Fold Difference	SD
1422470_at	Bnip3	BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3	7.83	± 2.26
1452094_at	P4ha1	Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	3.46	± 0.60
1421830_at	Ak3l1	Adenylate kinase 3-like 1	3.09	± 0.58
1418025_at	Bhlhe40	Basic helix-loop-helix family, member e40	2.54	± 0.04
1426599_a_at	Slc2a1	Solute carrier family 2 (facilitated glucose transporter), member 1	2.24	± 0.03
1420909_at	Vegfa	Vascular endothelial growth factor A	2.19	± 0.48
1422612_at	Hk2	Hexokinase 2	2.08	± 0.20
1416488_at	Ccng2	Cyclin G2	2.05	± 0.60
1417149_at	P4ha2	Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide	2.05	± 0.12

List of HIF-1α target genes found in the gene expression profile experiment as upregulated in response to hypoxia in GL261 control cells. For each gene the Affymetrix ID, the gene symbol, gene title, average fold difference and standard deviation (n = 2) are shown.

ISSN: 1476-4598